临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
JOURNAL OF CLINICAL PSYCHOSOMATIC DISEASES
2014年
3期
33-35,58
,共4页
魏长礼%周东林%牛慧明%洪贵子%裴根详%穆小梅%邓建勋%庞润慧%候宁%马元业%李军强%丁志杰
魏長禮%週東林%牛慧明%洪貴子%裴根詳%穆小梅%鄧建勛%龐潤慧%候寧%馬元業%李軍彊%丁誌傑
위장례%주동림%우혜명%홍귀자%배근상%목소매%산건훈%방윤혜%후저%마원업%리군강%정지걸
围绝经期抑郁症%心身疾病%心身健康%曲唑酮%氟西汀%汉密顿抑郁量表%汉密顿焦虑量表
圍絕經期抑鬱癥%心身疾病%心身健康%麯唑酮%氟西汀%漢密頓抑鬱量錶%漢密頓焦慮量錶
위절경기억욱증%심신질병%심신건강%곡서동%불서정%한밀돈억욱량표%한밀돈초필량표
Perimenopausal depression%psychosomatic disease%psychosomatic health%trazodone%fluoxe-tine%HAMD%HAMA
目的：探讨曲唑酮与氟西汀治疗围绝经期抑郁症的临床疗效和安全性。方法将72例围绝经期抑郁症患者随机分为两组，每组36例，研究组口服曲唑酮治疗，对照组口服氟西汀治疗，观察6周。于治疗前后采用汉密顿抑郁量表、汉密顿焦虑量表评定临床疗效，副反应量表评定不良反应。结果研究组治疗1周末汉密顿焦虑量表总分、汉密顿抑郁量表总分及睡眠因子分显著低于对照组（ P＜0．05）；治疗6周末研究组显效率86．1％、有效率94．4％，对照组分别为77．8％、94．4％，两组比较差异无显著性（χ2＝0．84、0，P＞0．05）。研究组失眠及焦虑不安发生率显著低于对照组（P＜0．05）。结论曲唑酮与氟西汀治疗围绝经期抑郁症疗效均显著，但曲唑酮能够较快改善患者的焦虑及睡眠状况，治疗依从性更好。
目的：探討麯唑酮與氟西汀治療圍絕經期抑鬱癥的臨床療效和安全性。方法將72例圍絕經期抑鬱癥患者隨機分為兩組，每組36例，研究組口服麯唑酮治療，對照組口服氟西汀治療，觀察6週。于治療前後採用漢密頓抑鬱量錶、漢密頓焦慮量錶評定臨床療效，副反應量錶評定不良反應。結果研究組治療1週末漢密頓焦慮量錶總分、漢密頓抑鬱量錶總分及睡眠因子分顯著低于對照組（ P＜0．05）；治療6週末研究組顯效率86．1％、有效率94．4％，對照組分彆為77．8％、94．4％，兩組比較差異無顯著性（χ2＝0．84、0，P＞0．05）。研究組失眠及焦慮不安髮生率顯著低于對照組（P＜0．05）。結論麯唑酮與氟西汀治療圍絕經期抑鬱癥療效均顯著，但麯唑酮能夠較快改善患者的焦慮及睡眠狀況，治療依從性更好。
목적：탐토곡서동여불서정치료위절경기억욱증적림상료효화안전성。방법장72례위절경기억욱증환자수궤분위량조，매조36례，연구조구복곡서동치료，대조조구복불서정치료，관찰6주。우치료전후채용한밀돈억욱량표、한밀돈초필량표평정림상료효，부반응량표평정불량반응。결과연구조치료1주말한밀돈초필량표총분、한밀돈억욱량표총분급수면인자분현저저우대조조（ P＜0．05）；치료6주말연구조현효솔86．1％、유효솔94．4％，대조조분별위77．8％、94．4％，량조비교차이무현저성（χ2＝0．84、0，P＞0．05）。연구조실면급초필불안발생솔현저저우대조조（P＜0．05）。결론곡서동여불서정치료위절경기억욱증료효균현저，단곡서동능구교쾌개선환자적초필급수면상황，치료의종성경호。
Objective To explore the efficacy and safety of trazodone versus fluoxetine in perimenopausal depression .Method Seventy-two patients with perimenopausal depression were randomly assigned to two groups of 36 ones each ,research group took orally trazodone and control group did fluoxetine for 6 weeks . Efficacies were assessed with the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HA-MA ) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS) .Results At the end of the 1st week the HAMA total ,HAMD total and sleep score were signifi-cantly lower in research than in control group (P<0 .05);at the end of the 6th week obvious effective and effective rate were respectively 86 .1% and 94 .4% in research and 77 .8% and 94 .4% in control group , which showed no significant differences (χ2 =0 .84 ,0 ;P>0 .05) .The incidences of insomnia and dysphori-a were significantly lower in research than in control group (P<0 .05) .Conclusion Both trazodone and fluoxetine have an evident effect in the treatment of perimenopausal depression ,but the former could im-prove patients’ anxiety and sleep status more rapidly and has better compliance .
