CAJ | 학술논문

目的：探讨帕罗西汀联合丁螺环酮治疗抑郁症的临床疗效和安全性。方法将80例抑郁症患者随机分为两组，每组40例，两组均口服帕罗西汀治疗，研究组联合丁螺环酮治疗，观察6周。于治疗前后采用汉密顿抑郁量表、汉密顿焦虑量表评定临床疗效，副反应量表评定不良反应。结果治疗6周末研究组显效率为70．0％、有效率为90．0％，对照组分别为42．5％、85．0％，研究组显效率显著高于对照组（χ2＝6．15，P＜0．05）。两组不良反应较轻微，同期副反应量表评分比较差异无显著性（P＞0．05）。结论帕罗西汀联合丁螺环酮治疗抑郁症具有增效作用，疗效显著，起效快，且不增加不良反应，显著优于单用帕罗西汀治疗。
목적：탐토파라서정연합정라배동치료억욱증적림상료효화안전성。방법장80례억욱증환자수궤분위량조，매조40례，량조균구복파라서정치료，연구조연합정라배동치료，관찰6주。우치료전후채용한밀돈억욱량표、한밀돈초필량표평정림상료효，부반응량표평정불량반응。결과치료6주말연구조현효솔위70．0％、유효솔위90．0％，대조조분별위42．5％、85．0％，연구조현효솔현저고우대조조（χ2＝6．15，P＜0．05）。량조불량반응교경미，동기부반응량표평분비교차이무현저성（P＞0．05）。결론파라서정연합정라배동치료억욱증구유증효작용，료효현저，기효쾌，차불증가불량반응，현저우우단용파라서정치료。
Objective To explore the efficacy and safety of paroxetine combined with buspirone in the treatment of depression .Methods Eighty depression pa-tients were randomly assigned to two groups of 40 ones each ,both groups took o-rally paroxetine ,and research group was plus buspirone for 6 weeks .Efficacies were assessed with the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) before and after treatment .Re-sults At the end of the 6th week obvious effective and effective rate were respectively 70 .0% and 90 .0% in research and 42 .5% and 85 .0% in control group ,obvious effective rate was significantly higher in the for-mer than in the latter (χ2 =6 .15 ,P<0 .05) .Adverse reactions of both groups were mild ,there were no significant group differences in the TESS scores (P>0 .05) .Conclusion Paroxetine combined with buspi-rone has a synergistic action and an evident effect ,takes effect more rapidly ,and doesn’t increase adverse reactions compared with single-use paroxetine in the treatment of depression .