CAJ | 학술논문

目的：探讨组织弥散定量分析参数应变均值在判定肝纤维化程度上的价值。方法慢性乙型肝炎患者130例，肝穿前均行组织弥散定量参数分析，分析参数应变均值在不同程度肝纤维化上的表现。所有病例均经病理证实。结果肝纤维化不同病理分期应变均值之间的差异均具有统计学意义。运用ROC曲线界定应变均值在判定S≥1、S≥2、S≥3和S=4上的诊断界点分别约为：116.2、111.4、101.6、97.5，其诊断敏感性分别为91.2%、90.8%、95.8%和89.7%；特异性分别为90.4%、98.6%、93.8%和95.6%；准确度分别为90.6%、94.7%、95.5%和91.8%。结论组织弥散定量参数应变均值在判定肝纤维化不同程度上能够给出具体数值，具有较好的价值。
목적：탐토조직미산정량분석삼수응변균치재판정간섬유화정도상적개치。방법만성을형간염환자130례，간천전균행조직미산정량삼수분석，분석삼수응변균치재불동정도간섬유화상적표현。소유병례균경병리증실。결과간섬유화불동병리분기응변균치지간적차이균구유통계학의의。운용ROC곡선계정응변균치재판정S≥1、S≥2、S≥3화S=4상적진단계점분별약위：116.2、111.4、101.6、97.5，기진단민감성분별위91.2%、90.8%、95.8%화89.7%；특이성분별위90.4%、98.6%、93.8%화95.6%；준학도분별위90.6%、94.7%、95.5%화91.8%。결론조직미산정량삼수응변균치재판정간섬유화불동정도상능구급출구체수치，구유교호적개치。
Objective To explore the value of the strain means of the quantitative parameters of organization diffusion in determining the degree of liver fibrosis. Methods A total of 130 patients with chronic hepatitis B were examined for quantitative analysis of organization diffusion before liver biopsy to analyze the performance of the strain means in liver fibrosis of different degrees. All the cases were confirmed by pathology. Results The strain means differed significantly between different stages of liver fibrosis. Using the best cut-off values of 116.2, 111.4, 101.6 and 97.5 for diagnosis of S≥1, S≥2, S≥3 and S=4, the diagnostic sensitivities were 91.2%, 90.8%, 95.8% and 89.7%, with specificities of 90.4%, 98.6%, 93.8% and 95.6% and accuracies of 90.6%, 94.7%, 95.5% and 91.8%, respectively. Conclusion The strain mean can provide specific numerical indicators to determine the degree of liver fibrosis.