中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2013年
8期
593-596
,共4页
张丽娜%杨艳芳%刘君%姜战胜%顾林
張麗娜%楊豔芳%劉君%薑戰勝%顧林
장려나%양염방%류군%강전성%고림
乳腺肿瘤%乳房切除术,区段%年龄因素%预后
乳腺腫瘤%乳房切除術,區段%年齡因素%預後
유선종류%유방절제술,구단%년령인소%예후
Breast neoplasms%Masectomy,segmental%Age factors%Prognosis
目的 分析年轻乳腺癌患者行保乳手术治疗的临床特点及预后因素.方法 回顾性分析1998年1月至2008年7月接受保乳手术的605例患者的临床资料,根据年龄将其分为年轻组(年龄≤35岁,n=110例)和中老年组(年龄＞35岁,n=495例).COX比例风险模型进行多因素分析,确定影响预后的独立因素.结果 中位随访61个月,年轻组和老年组的5年无局部复发生存率分别为92.6％和96.8％,差异无统计学意义(P=0.074)；5年无远处转移生存率和总生存率分别为89.7％、95.2％(P=0.001)和96.4％、98.9％ (P =0.046),年轻组预后较老年组差,差异有统计学意义.多因素分析显示淋巴结转移和辅助放疗是影响保乳手术局部复发的独立危险因素,而年龄、淋巴结转移和辅助放疗是影响远处转移和总生存的独立危险因素.结论 年龄并非是影响保乳术后局部复发的独立危险因素,放疗可以降低局部复发风险,亦能减少远处转移,提高总生存率.
目的 分析年輕乳腺癌患者行保乳手術治療的臨床特點及預後因素.方法 迴顧性分析1998年1月至2008年7月接受保乳手術的605例患者的臨床資料,根據年齡將其分為年輕組(年齡≤35歲,n=110例)和中老年組(年齡＞35歲,n=495例).COX比例風險模型進行多因素分析,確定影響預後的獨立因素.結果 中位隨訪61箇月,年輕組和老年組的5年無跼部複髮生存率分彆為92.6％和96.8％,差異無統計學意義(P=0.074)；5年無遠處轉移生存率和總生存率分彆為89.7％、95.2％(P=0.001)和96.4％、98.9％ (P =0.046),年輕組預後較老年組差,差異有統計學意義.多因素分析顯示淋巴結轉移和輔助放療是影響保乳手術跼部複髮的獨立危險因素,而年齡、淋巴結轉移和輔助放療是影響遠處轉移和總生存的獨立危險因素.結論 年齡併非是影響保乳術後跼部複髮的獨立危險因素,放療可以降低跼部複髮風險,亦能減少遠處轉移,提高總生存率.
목적 분석년경유선암환자행보유수술치료적림상특점급예후인소.방법 회고성분석1998년1월지2008년7월접수보유수술적605례환자적림상자료,근거년령장기분위년경조(년령≤35세,n=110례)화중노년조(년령＞35세,n=495례).COX비례풍험모형진행다인소분석,학정영향예후적독립인소.결과 중위수방61개월,년경조화노년조적5년무국부복발생존솔분별위92.6％화96.8％,차이무통계학의의(P=0.074)；5년무원처전이생존솔화총생존솔분별위89.7％、95.2％(P=0.001)화96.4％、98.9％ (P =0.046),년경조예후교노년조차,차이유통계학의의.다인소분석현시림파결전이화보조방료시영향보유수술국부복발적독립위험인소,이년령、림파결전이화보조방료시영향원처전이화총생존적독립위험인소.결론 년령병비시영향보유술후국부복발적독립위험인소,방료가이강저국부복발풍험,역능감소원처전이,제고총생존솔.
Objective To identify the clinical characteristics and prognostic factors in young women of breast cancer treated with breast conservation therapy.Methods Clinical data of 605 cases of breast cancer patients undergoing breast conserving therapy were reviewed in our hospital from Jan 1998 to July 2008.According to their age,these patients were divided into young group (age≤ 35 years,n =110 cases) and the elderly group (age ＞ 35 years,n =495 cases).Survival factors were analyzed by Cox proportional hazards regression model.Results During the median follow-up of 61 months,the 5-year local-regional relapse-free survival was 92.6％ and 96.8％,respectively (P =0.074) ; the 5-year distant metastasis-free survival and overall survival between the two groups were (89.7％ vs.95.2％,P =0.001)and (96.4％ vs.98.9％,P =0.046).Multivariate analysis revealed that lymph node metastasis and adjuvant radiotherapy were independent risk factors for local-regional relapse.Distant metastasis and overall survival were determined by lymph node metastasis,adjuvant radiotherapy and age.Conclusions Age is not an independent factors affecting tumor local recurrence in Chinese young female patients of early breast cancer receiving breast conserving surgical therapy.
