CAJ | 학술논문

目的观察蒙古苍耳子不同提取物的抗炎镇痛作用,并与苍耳子进行比较。方法雄性昆明小鼠70只,分为空白对照组、阿司匹林组、苍耳子乙醇提取物组、蒙古苍耳子乙醇提取物组、蒙古苍耳子乙醚提取物组、蒙古苍耳子乙酸乙酯萃取物组、蒙古苍耳子正丁醇萃取物组,共7组,各10只,按500 mg·kg-1灌胃给药,采用小鼠热板实验观察其镇痛作用,二甲苯致小鼠耳肿胀实验观察其抗炎作用。结果在小鼠热板实验中,灌服苍耳子乙醇提取物和蒙古苍耳子各种提取物60,120及180 min后,小鼠的痛阈值均延长(P<0.05),苍耳子乙醇提取物组和蒙古苍耳子乙醇提取物组的痛阈值差异无统计学意义(P>0.05),蒙古苍耳子乙醚提取组和正丁醇萃取组镇痛效果最好。在二甲苯致小鼠耳肿胀实验中,苍耳子乙醇提取物和蒙古苍耳子各部位提取物对二甲苯所致的小鼠耳廓肿胀均有明显的抑制作用(均P<0.05),苍耳子乙醇提取物组和蒙古苍耳子乙醇提取物组间差异无统计学意义(P>0.05),蒙古苍耳子乙醚提取组和正丁醇萃取组抗炎效果最好(P<0.05)。结论蒙古苍耳子有较强的抗炎镇痛作用,与苍耳子相似,且以乙醚提取物和正丁醇萃取部位抗炎镇痛效果最好。
목적관찰몽고창이자불동제취물적항염진통작용,병여창이자진행비교。방법웅성곤명소서70지,분위공백대조조、아사필림조、창이자을순제취물조、몽고창이자을순제취물조、몽고창이자을미제취물조、몽고창이자을산을지췌취물조、몽고창이자정정순췌취물조,공7조,각10지,안500 mg·kg-1관위급약,채용소서열판실험관찰기진통작용,이갑분치소서이종창실험관찰기항염작용。결과재소서열판실험중,관복창이자을순제취물화몽고창이자각충제취물60,120급180 min후,소서적통역치균연장(P<0.05),창이자을순제취물조화몽고창이자을순제취물조적통역치차이무통계학의의(P>0.05),몽고창이자을미제취조화정정순췌취조진통효과최호。재이갑분치소서이종창실험중,창이자을순제취물화몽고창이자각부위제취물대이갑분소치적소서이곽종창균유명현적억제작용(균P<0.05),창이자을순제취물조화몽고창이자을순제취물조간차이무통계학의의(P>0.05),몽고창이자을미제취조화정정순췌취조항염효과최호(P<0.05)。결론몽고창이자유교강적항염진통작용,여창이자상사,차이을미제취물화정정순췌취부위항염진통효과최호。
Objective To investigate the anti-inflammatory and analgesic activities of different extracts from X. mongolicum compared with that of X. sibiricum. Methods Seventy male Kunming mices were randomly divided into seven groups:control group,aspirin group,the ethanol extracts of X. sibiricum group and X. mongolicum group,the extracts from X. mongolicum with ether,ethyl acetate,and n-butyl alcohol group(n=10 each). The mice were administrated with 500 mg·kg-1 ( p. o. ) of different extracts. The hot-plate tests and the xylene-induced ear edema in mice were performed to observe the analgesic and anti-inflammatory activities,respectively. Results In the hot-plate tests,the pain threshold from the extracts of X. sibiricum and the different extracts from X. mongolicum at 60,120,180 min were prolonged,and there was no statistically significant differences(P>0. 05) between the ethanol extracts from X. sibiricum and X. mongolicum. The best analgesic activity was the ether and butyl alcohol extracts from X. mongolicum. Meanwile,the ear edema from the extracts of X. sibiricum and the different extracts of X. mongolicum were inhibited significantly(P<0. 05). There was also no significant differences between the ethanol extracts of X. sibiricum and X. mongolicum(P>0. 05). The ether and butyl alcohol extracts from of X. mongolicum showed the best anti-inflammatory effect. Conclusion X. mongolicum exhibites significant anti-inflammatory and analgesic activities comparable to that of X. sibiricum. The best anti-inflammation and analgesic activities were from ether and butyl alcohol extracts from X. mongolicum.