中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
6期
1014-1017
,共4页
杨海燕%郑萍%赵绍林%陈新宽%吴惠毅
楊海燕%鄭萍%趙紹林%陳新寬%吳惠毅
양해연%정평%조소림%진신관%오혜의
糖尿病肾病%肾小球滤过率%β痕迹蛋白
糖尿病腎病%腎小毬濾過率%β痕跡蛋白
당뇨병신병%신소구려과솔%β흔적단백
Diabetic nephropathies%Glomerular filtration rate%Beta trace protein
目的:探讨血、尿β痕迹蛋白(βTP)检测在2型糖尿病肾损伤中的诊断价值。方法明确诊断为2型糖尿病患者178例,按照尿Alb/Cr比值将其分为三组:Alb/Cr正常组60例,微量白蛋白尿组65例,大量白蛋白尿组53例,另设健康对照组80名。采用胶乳增强散射免疫比浊法原理检测血、尿βTP,比较各组患者血、尿βTP水平,并与Scr、eGFR以及实验及临床相关指标进行相关性分析。结果尿Alb/Cr正常的2型糖尿病患者血清βTP为(0.70±0.36)mg/dl,较健康对照组[(0.59±0.12)mg/dl]显著升高(P<0.01)。微量白蛋白尿组血清βTP(0.82±0.30)mg/dl,较Alb/Cr正常组显著升高(P<0.05);大量白蛋白尿组血清βTP(1.79±1.19)mg/dl,与其他两组比较显著升高(P<0.01);三组2型糖尿病患者血清βTP阳性率分别为28.3%、60.0%和87.8%;尿液βTP/Cr阳性率分别为20%、84.6%和90.6%。相关分析结果表明,血清βTP与SC呈显著正相关,r为0.7050(P<0.01),eGFR值与血β-TP呈显著负相关(r=-0.8051,P<0.01)。尿βTP与Scr、HbA1c、收缩压、病程呈正相关(r分别为0.3879、0.2402、0.1643、0.2415,均P<0.05)。结论血清βTP对2型糖尿病患者早期肾损伤具有重要的诊断价值,可以早期反映肾小球滤过功能,而尿βTP/Cr可以作为评价2型糖尿病患者肾小管损伤的有效指标。
目的:探討血、尿β痕跡蛋白(βTP)檢測在2型糖尿病腎損傷中的診斷價值。方法明確診斷為2型糖尿病患者178例,按照尿Alb/Cr比值將其分為三組:Alb/Cr正常組60例,微量白蛋白尿組65例,大量白蛋白尿組53例,另設健康對照組80名。採用膠乳增彊散射免疫比濁法原理檢測血、尿βTP,比較各組患者血、尿βTP水平,併與Scr、eGFR以及實驗及臨床相關指標進行相關性分析。結果尿Alb/Cr正常的2型糖尿病患者血清βTP為(0.70±0.36)mg/dl,較健康對照組[(0.59±0.12)mg/dl]顯著升高(P<0.01)。微量白蛋白尿組血清βTP(0.82±0.30)mg/dl,較Alb/Cr正常組顯著升高(P<0.05);大量白蛋白尿組血清βTP(1.79±1.19)mg/dl,與其他兩組比較顯著升高(P<0.01);三組2型糖尿病患者血清βTP暘性率分彆為28.3%、60.0%和87.8%;尿液βTP/Cr暘性率分彆為20%、84.6%和90.6%。相關分析結果錶明,血清βTP與SC呈顯著正相關,r為0.7050(P<0.01),eGFR值與血β-TP呈顯著負相關(r=-0.8051,P<0.01)。尿βTP與Scr、HbA1c、收縮壓、病程呈正相關(r分彆為0.3879、0.2402、0.1643、0.2415,均P<0.05)。結論血清βTP對2型糖尿病患者早期腎損傷具有重要的診斷價值,可以早期反映腎小毬濾過功能,而尿βTP/Cr可以作為評價2型糖尿病患者腎小管損傷的有效指標。
목적:탐토혈、뇨β흔적단백(βTP)검측재2형당뇨병신손상중적진단개치。방법명학진단위2형당뇨병환자178례,안조뇨Alb/Cr비치장기분위삼조:Alb/Cr정상조60례,미량백단백뇨조65례,대량백단백뇨조53례,령설건강대조조80명。채용효유증강산사면역비탁법원리검측혈、뇨βTP,비교각조환자혈、뇨βTP수평,병여Scr、eGFR이급실험급림상상관지표진행상관성분석。결과뇨Alb/Cr정상적2형당뇨병환자혈청βTP위(0.70±0.36)mg/dl,교건강대조조[(0.59±0.12)mg/dl]현저승고(P<0.01)。미량백단백뇨조혈청βTP(0.82±0.30)mg/dl,교Alb/Cr정상조현저승고(P<0.05);대량백단백뇨조혈청βTP(1.79±1.19)mg/dl,여기타량조비교현저승고(P<0.01);삼조2형당뇨병환자혈청βTP양성솔분별위28.3%、60.0%화87.8%;뇨액βTP/Cr양성솔분별위20%、84.6%화90.6%。상관분석결과표명,혈청βTP여SC정현저정상관,r위0.7050(P<0.01),eGFR치여혈β-TP정현저부상관(r=-0.8051,P<0.01)。뇨βTP여Scr、HbA1c、수축압、병정정정상관(r분별위0.3879、0.2402、0.1643、0.2415,균P<0.05)。결론혈청βTP대2형당뇨병환자조기신손상구유중요적진단개치,가이조기반영신소구려과공능,이뇨βTP/Cr가이작위평개2형당뇨병환자신소관손상적유효지표。
Objective To study the diagnostic value of the serum and urine beta trace protein (βTP) in type 2 diabetes with renal injury. Methods 178 type 2 diabetes patients with confirmed diagnosis were classified into three groups according to the ratio of urine albumin to creatinine (Alb/Cr) as follows: 60 in normal Alb/Cr group, 65 in microalbuminuria group, 40 in macroalbuminuria group. 60 healthy subjects serve as normal control group. The concentrations of serum and urineβTP were measured using latex particle enhanced immunoturbidimetry assay and compared among all groups and made the correlation analysis with serum creatinine (Scr), estimated glomerular filtration rate (eGFR), the other laboratory and clinical related indexes. Results The serumβTP in normal Alb/Cr group was higher than that in healthy control group (0.70±0.36)mg/dl vs. (0.59±0.12)mg/dl, P<0.01, however, was lower than that in microalbuminuria group (0.82±0.30)mg/dl vs. (0.59±0.12)mg/dl, P<0.05. The serum βTP of macroalbuminuria group significantly increased compared to normal Alb/Cr and microalbuminuria group (both P<0.01). The positive rates of serum and urineβTP in three groups of type 2 diabetes patients were 28.3%, 60.0%, 87.8% and 20%, 84.6%, 90.6% respectively. The correlation analysis showed serumβTP were positively correlated with Scr(r=0.7050, P<0.01) and were negatively correlated with eGFR (r=-0.8051, P<0.01). The ratio of urineβTP to creatinine (βTP/Cr) were positively correlated with Scr (r=0.3879, P<0.05), HbA1c(r=0.2402, P<0.05), systolic pressure(r=0.1643, P<0.05) and course of the disease(r=0.2415, P<0.05). Conclusion The serum BTP has an important diagnostic value at the early renal injury of type 2 diabetic patients and can reflect accurately the glomerular filtration function. The urineβTP/Cr can be applied to evaluated availably renal tubular damage of type 2 diabetes patients.