CAJ | 학술논문

Irisin是一种新发现的肌因子，目前为数不多的研究认为它可促进白色脂肪棕色化，加快新陈代谢，从而减轻体重、增加能量释放以及调节葡萄糖稳态，认为它与运动、肥胖、胰岛素抵抗等密切相关，但还存在很多争议和分歧，需要更多的大样本研究去探索Irisin的病理生理机制及其受体的特征，从而为临床治疗肥胖及相关代谢性疾病甚至是阿尔茨海默尔等神经系统疾病寻求新靶点。
Irisin시일충신발현적기인자，목전위수불다적연구인위타가촉진백색지방종색화，가쾌신진대사，종이감경체중、증가능량석방이급조절포도당은태，인위타여운동、비반、이도소저항등밀절상관，단환존재흔다쟁의화분기，수요경다적대양본연구거탐색Irisin적병리생리궤제급기수체적특정，종이위림상치료비반급상관대사성질병심지시아이자해묵이등신경계통질병심구신파점。
Irisin is a recently identified myokine.Few studies have found that irisin promotes brown adipocyte recruitment in white fat by increasing energy expenditure,which is helpful for losing weight,increasing energy release and regulating glucose homeostasis.Some studies think that it is closely related to exercise,obesity,insulin resistance and so on,but there are still a lot of disputes,and more large sample researches are needed to explore the pathophysiological characteristics of irisin and its receptor,thereby we can find new treat-ment for obesity and related metabolic diseases,and even for the nervous system disease such as Alzheimer’s diseases.