中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
8期
1418-1422
,共5页
石祥东%孟令新%丁兆军%孙树艳%梁粉花%王刚平
石祥東%孟令新%丁兆軍%孫樹豔%樑粉花%王剛平
석상동%맹령신%정조군%손수염%량분화%왕강평
受体,表皮生长因子%受体,erbB-2%缺氧诱导因子1,α亚基%食管肿瘤%肿瘤,鳞状细胞
受體,錶皮生長因子%受體,erbB-2%缺氧誘導因子1,α亞基%食管腫瘤%腫瘤,鱗狀細胞
수체,표피생장인자%수체,erbB-2%결양유도인자1,α아기%식관종류%종류,린상세포
Receptor,epidermal growth factor%Receptor,erbB-2%Hypoxia-inducible factor 1,alpha subunit%Esophageal neoplasms%Neoplasms,squamous cell
目的：研究EGFR、Her-2和HIF-1α在食管鳞癌中的表达，探讨三者的表达与食管鳞癌临床病理学特征之间的关系及三者之间的相关性。方法应用免疫组化 Envision 二步法检测80例食管鳞癌的切除标本和40例正常鳞状上皮组织中EGFR、Her-2和HIF-1α的表达。结果 HIF-1α、EGFR、Her-2在食管鳞癌及癌旁正常鳞状上皮组织表达阳性率分别为62.5%vs.0.0%（P＝0.000）、67.5%vs.12.5%（P＝0.000）和7.5%vs.0.0%（P＝0.183）。HIF-1α、Her-2、EGFR表达均与肿瘤细胞分化、TNM 分期、淋巴结转移有关，与性别、年龄无关。食管鳞癌中HIF-1α的表达与EGFR、Her-2的表达正相关（r＝0.565，P＝0.000；r＝0.221，P＝0.039）；食管鳞癌中Her-2与EGFR表达无相关性（r＝0.198，P＝0.079）。结论 HIF-1α、EGFR在食管鳞癌高表达，可能在食管鳞癌的发生发展中起重要作用，可作为监测肿瘤发生、预测转移和预后的有用指标，有可能成为靶向治疗的新靶点。而Her-2因在食管鳞癌表达阳性率低不适合成为靶向治疗的靶点。
目的：研究EGFR、Her-2和HIF-1α在食管鱗癌中的錶達，探討三者的錶達與食管鱗癌臨床病理學特徵之間的關繫及三者之間的相關性。方法應用免疫組化 Envision 二步法檢測80例食管鱗癌的切除標本和40例正常鱗狀上皮組織中EGFR、Her-2和HIF-1α的錶達。結果 HIF-1α、EGFR、Her-2在食管鱗癌及癌徬正常鱗狀上皮組織錶達暘性率分彆為62.5%vs.0.0%（P＝0.000）、67.5%vs.12.5%（P＝0.000）和7.5%vs.0.0%（P＝0.183）。HIF-1α、Her-2、EGFR錶達均與腫瘤細胞分化、TNM 分期、淋巴結轉移有關，與性彆、年齡無關。食管鱗癌中HIF-1α的錶達與EGFR、Her-2的錶達正相關（r＝0.565，P＝0.000；r＝0.221，P＝0.039）；食管鱗癌中Her-2與EGFR錶達無相關性（r＝0.198，P＝0.079）。結論 HIF-1α、EGFR在食管鱗癌高錶達，可能在食管鱗癌的髮生髮展中起重要作用，可作為鑑測腫瘤髮生、預測轉移和預後的有用指標，有可能成為靶嚮治療的新靶點。而Her-2因在食管鱗癌錶達暘性率低不適閤成為靶嚮治療的靶點。
목적：연구EGFR、Her-2화HIF-1α재식관린암중적표체，탐토삼자적표체여식관린암림상병이학특정지간적관계급삼자지간적상관성。방법응용면역조화 Envision 이보법검측80례식관린암적절제표본화40례정상린상상피조직중EGFR、Her-2화HIF-1α적표체。결과 HIF-1α、EGFR、Her-2재식관린암급암방정상린상상피조직표체양성솔분별위62.5%vs.0.0%（P＝0.000）、67.5%vs.12.5%（P＝0.000）화7.5%vs.0.0%（P＝0.183）。HIF-1α、Her-2、EGFR표체균여종류세포분화、TNM 분기、림파결전이유관，여성별、년령무관。식관린암중HIF-1α적표체여EGFR、Her-2적표체정상관（r＝0.565，P＝0.000；r＝0.221，P＝0.039）；식관린암중Her-2여EGFR표체무상관성（r＝0.198，P＝0.079）。결론 HIF-1α、EGFR재식관린암고표체，가능재식관린암적발생발전중기중요작용，가작위감측종류발생、예측전이화예후적유용지표，유가능성위파향치료적신파점。이Her-2인재식관린암표체양성솔저불괄합성위파향치료적파점。
Objective To explore EGFR, Her-2, HIF-1 alpha expression in esophageal squamous cell carcinoma(ESCC) and investigate the relationship between clinical pathological features in esophageal squamous carcinoma and the correlation between the three index. Methods Immunohistochemical Envision two-steps method was applied to assay EGFR, Her-2, HIF-1 alpha expression in 80 cases specimens of ESCC and 40 cases of adjacent normal squamous epithelial tissues. Results HIF-1 alpha, EGFR and Her-2 in ESCC and adjacent normal squamous epithelial tissues positive expression rate were 62.5% vs. 0.0% (P=0.000), 67.5% vs. 12.5% (P=0.000), 7.5% vs. 0.0% (P=0.183) each other. The expression of HIF-1 alpha, Her-2, EGFR had correlation with tumor cell differentiation, TNM staging and lymph node metastasis, had nothing to do with gender, age. HIF-1 alpha expression in esophageal squamous carcinoma had positive correlation with EGFR and Her-2, correlation coefficient were 0.565(P=0.000) and 0.221 (P=0.039). However, EGFR had no correlation with Her-2, correlation coefficient was 0.198(P=0.079). Conclusions EGFR and HIF-1 alpha high expression may plays an important role in tumor genesis and development of ESCC, may be used as useful indicators for predicating tumor genesis, metastasis, prognosis and may be likely to become new target for targeted therapy of ESCC. Her-2 expression was low in ESCC, and may be not suitable for be targeted therapy targets.
