中华细胞与干细胞杂志（电子版）
中華細胞與榦細胞雜誌（電子版）
중화세포여간세포잡지（전자판）
CHINESE JOURNAL OF CELL AND STEM CELL
2014年
1期
67-71
,共5页
殷秋菊%赵娉婷%杨春波%李筱荣
慇鞦菊%趙娉婷%楊春波%李篠榮
은추국%조빙정%양춘파%리소영
信号通路%β-Catenin%视网膜%上皮细胞
信號通路%β-Catenin%視網膜%上皮細胞
신호통로%β-Catenin%시망막%상피세포
Signaling pathway%β-Catenin%Retian%Epithelial cell
Wnt（wingless-type MMTV integration site family members）信号通路与细胞的发育分化密切相关，尤其对动物胚胎期中枢神经系统的发育至关重要。在眼的早期发育中，视泡背部视网膜色素上皮细胞（RPE）Wnt/βcatenin信号通路高度活跃，对神经视网膜及RPE的发育调控起重要作用。本文结合目前该领域研究进展，综合评述Wnt信号通路、Wnt蛋白家族以及Wnt信号通路与RPE发育的关系。
Wnt（wingless-type MMTV integration site family members）信號通路與細胞的髮育分化密切相關，尤其對動物胚胎期中樞神經繫統的髮育至關重要。在眼的早期髮育中，視泡揹部視網膜色素上皮細胞（RPE）Wnt/βcatenin信號通路高度活躍，對神經視網膜及RPE的髮育調控起重要作用。本文結閤目前該領域研究進展，綜閤評述Wnt信號通路、Wnt蛋白傢族以及Wnt信號通路與RPE髮育的關繫。
Wnt（wingless-type MMTV integration site family members）신호통로여세포적발육분화밀절상관，우기대동물배태기중추신경계통적발육지관중요。재안적조기발육중，시포배부시망막색소상피세포（RPE）Wnt/βcatenin신호통로고도활약，대신경시망막급RPE적발육조공기중요작용。본문결합목전해영역연구진전，종합평술Wnt신호통로、Wnt단백가족이급Wnt신호통로여RPE발육적관계。
Wnt signaling plays important roles in embryonic development and cell differentiation, especially during central nervous system (CNS) development. At the early stage of eye development, retinal pigment epithelium (RPE) in the dorsal optic vesicle shows intensive Wnt/β-catenin signaling activity, which is critical for the development of neural retina and RPE. This review focuses on recent advances in the fields of Wnt signaling pathway, Wnt protein family and the relationship between Wnt signaling and RPE development and differentiation.
