CAJ | 학술논문

目的：应用ROC曲线（receiver operating characteristic curve）分析SCC-Ag在早期食管癌诊断中的价值。方法：用酶联免疫（enzyme-linked immunosorbent assay，ELISA）法检测40例正常体检者和100例I-II期食管癌患者血清中SCC-Ag水平，应用ROC曲线进行分析。结果：早期食管癌患者SCC-Ag水平高于正常组，差异有统计学意义（p<0.000）；当SCC-Ag截断值为≥1.39 ng/ml，此截断值的灵敏度为92.0%，特异度为94.0%，诊断符合率为92.6%；曲线下面积为：0.973，P=0.000，95%CI：0.952-0.994，SCC-Ag曲线下面积AUC（are under curve）为0.748， P=0.000，95%CI：0.636-0.860，为食管癌最佳临床诊断临界点。结论：SCC-Ag水平变化可作为诊断早期食管癌的重要诊断依据。
목적：응용ROC곡선（receiver operating characteristic curve）분석SCC-Ag재조기식관암진단중적개치。방법：용매련면역（enzyme-linked immunosorbent assay，ELISA）법검측40례정상체검자화100례I-II기식관암환자혈청중SCC-Ag수평，응용ROC곡선진행분석。결과：조기식관암환자SCC-Ag수평고우정상조，차이유통계학의의（p<0.000）；당SCC-Ag절단치위≥1.39 ng/ml，차절단치적령민도위92.0%，특이도위94.0%，진단부합솔위92.6%；곡선하면적위：0.973，P=0.000，95%CI：0.952-0.994，SCC-Ag곡선하면적AUC（are under curve）위0.748， P=0.000，95%CI：0.636-0.860，위식관암최가림상진단림계점。결론：SCC-Ag수평변화가작위진단조기식관암적중요진단의거。
Objective:To explove the diagnostic significance of SCC-Ag in early esophageal cancer By ROC curve. Methods:Serum SCC-Ag level was detected with enzyme-linked immunosorbent (ELISA)in 100 I-II patients with esophageal cancer surgery and 50 cases with normal physical examination,Analysis of the application of ROC curve.Results:SCC-Ag level in early esophageal cancer patients was higher than that of the normal group, and the difference was statistically significant (p<0.000), When the SCC-Ag cutoff value is≥1.39 ng/ml, It is the best clinical diagnosis of esophageal cancer critical point.the sensitivity of the cutoff value was 92%, the specificity was 94%, the diagnostic coincidence rate was 92.6%;the area under the curve 0.973, P=0.000, 95%CI:0.952-0.994, the area under SCC-Ag curve of AUC (are under curve) was 0.748, P=0, 95%CI:0.636-0.860. Conclusions:The change of SCC-Ag level can be used as an important diagnostic basis for early esophageal cancer.