CAJ | 학술논문

目的：探讨人乳头瘤病毒（HPV）与EBV与宫颈癌的相关性。方法：分别取宫颈炎（32）和宫颈鳞癌患者组织标本（52）共84例,采用PCR方法对EBV和HPV DNA进行检测。结果：宫颈癌组HPV DNA、和EBV的阳性表达率分别为96.15％和69.23％，显著高于正常宫颈炎组3.13％和0，差异有统计学意义（P<0.05）；宫颈癌组HPV DNA和EBV混合感染率为67.31%,显著高于对照组，差异有统计学意义（P<0.05）。宫颈癌组患者分化程度：低分化组患者HPV+EBV阳性表达率高于高中分化组（P＜0.05）；临床分期：Ⅲ+Ⅳ期患者HPV+EBV阳性表达率高于Ⅰ+Ⅱ期患者（P＜0.05）；临床分型：浸润型患者HPV+EBV阳性表达率高于其他三型患者（P＜0.05）；淋巴转移：淋巴转移组患者HPV+EBV阳性表达率高于无淋巴转移组（P＜0.05）。且HPV(+)+EBV(+)患者的存活率明显低于HPV(+)组患者和EBV(+)组患者（P＜0.05）。结论：在宫颈癌组织中EBV及HPV有较高的感染率，且HPV+EBV+感染与宫颈癌分化程度、临床分期、分型、淋巴转移及预后密切相关。
목적：탐토인유두류병독（HPV）여EBV여궁경암적상관성。방법：분별취궁경염（32）화궁경린암환자조직표본（52）공84례,채용PCR방법대EBV화HPV DNA진행검측。결과：궁경암조HPV DNA、화EBV적양성표체솔분별위96.15％화69.23％，현저고우정상궁경염조3.13％화0，차이유통계학의의（P<0.05）；궁경암조HPV DNA화EBV혼합감염솔위67.31%,현저고우대조조，차이유통계학의의（P<0.05）。궁경암조환자분화정도：저분화조환자HPV+EBV양성표체솔고우고중분화조（P＜0.05）；림상분기：Ⅲ+Ⅳ기환자HPV+EBV양성표체솔고우Ⅰ+Ⅱ기환자（P＜0.05）；림상분형：침윤형환자HPV+EBV양성표체솔고우기타삼형환자（P＜0.05）；림파전이：림파전이조환자HPV+EBV양성표체솔고우무림파전이조（P＜0.05）。차HPV(+)+EBV(+)환자적존활솔명현저우HPV(+)조환자화EBV(+)조환자（P＜0.05）。결론：재궁경암조직중EBV급HPV유교고적감염솔，차HPV+EBV+감염여궁경암분화정도、림상분기、분형、림파전이급예후밀절상관。
Objective: To explore the correlation between the human papillomavirus (HPV) associated with EBV and cervical cancer.Methods:Taken the cervicitis (32) and cervical squamous cell carcinoma tissue specimens (52) of 84 cases, PCR method was used to detect the EBV and HPV DNA.Results: HPV DNA, and the EBV -positive expression rates of Cervical cancer group were 96.15% and 69.23% , significantly higher than 3.13% and 0 of cervicitis group , the difference was statistically significant (P <0.05); HPV DNA and EBV mixed infection rate of cervical cancer was 67.31% , significantly higher than the control group, the difference was statistically significant (P <0.05). Differentiation of cervical cancer patients : Patients with low differentiation degree show higher positive expression rate of HPV+EBV than that of high and middle differentiation groups (P < 0.05); clinical stage: patients with stage III + IV had higher positive expression rate of HPV+EBV than that of patients with stage Ⅰ + Ⅱ (P < 0.05); infiltrative expression in patients with HPV + EBV -positive patients was higher than the patients of other three types (P <0.05); Lymph node metastasis : patients with lymph node metastasis show higher HPV + EBV positive rate than those without lymph node metastasis (P <0.05). And the survival rate of patients with HPV (+) + EBV (+) was significantly lower than the patients with HPV (+) patients and EBV (+) patients (P <0.05).Conclusions:EBV and HPV in patients of cervical cancer have higher infection rate, and HPV+EBV+ infection is closely related to differentiation degree, clinical stage, lymph node metastasis, typing and prognosis of cervical cancer.