医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2014年
2期
15-17
,共3页
类风湿关节炎%不同时期%白介素-22
類風濕關節炎%不同時期%白介素-22
류풍습관절염%불동시기%백개소-22
Rheumatoid arthritis%Different periods%IL-22
目的:探讨IL-22在类风湿关节炎(rheumatoid arthritis,RA)不同时期患者中的临床意义。方法:用酶联免疫吸附法检测35例活动组RA患者、35例缓解组 RA 患者及30例健康人血清 IL-22的水平,并分析它与活动度和实验室指标的关系。结果:RA活动组和 RA 缓解组IL-22水平均明显高于对照组,差异均有统计学意义(p<0.05),而 RA 活动组与 RA 缓解组相比,差异亦有统计学意义(p<0.05)。RA 患者血清 IL-22与 DAS28评分、血沉、C 反应蛋白、类风湿因子均呈正相关关系(p<0.05)。结论:IL-22可能参与了 RA 的发病过程,并可将其血清水平作为RA活动参考指标。
目的:探討IL-22在類風濕關節炎(rheumatoid arthritis,RA)不同時期患者中的臨床意義。方法:用酶聯免疫吸附法檢測35例活動組RA患者、35例緩解組 RA 患者及30例健康人血清 IL-22的水平,併分析它與活動度和實驗室指標的關繫。結果:RA活動組和 RA 緩解組IL-22水平均明顯高于對照組,差異均有統計學意義(p<0.05),而 RA 活動組與 RA 緩解組相比,差異亦有統計學意義(p<0.05)。RA 患者血清 IL-22與 DAS28評分、血沉、C 反應蛋白、類風濕因子均呈正相關關繫(p<0.05)。結論:IL-22可能參與瞭 RA 的髮病過程,併可將其血清水平作為RA活動參攷指標。
목적:탐토IL-22재류풍습관절염(rheumatoid arthritis,RA)불동시기환자중적림상의의。방법:용매련면역흡부법검측35례활동조RA환자、35례완해조 RA 환자급30례건강인혈청 IL-22적수평,병분석타여활동도화실험실지표적관계。결과:RA활동조화 RA 완해조IL-22수평균명현고우대조조,차이균유통계학의의(p<0.05),이 RA 활동조여 RA 완해조상비,차이역유통계학의의(p<0.05)。RA 환자혈청 IL-22여 DAS28평분、혈침、C 반응단백、류풍습인자균정정상관관계(p<0.05)。결론:IL-22가능삼여료 RA 적발병과정,병가장기혈청수평작위RA활동삼고지표。
Objective:To investigate clinical significance of changes of the serum IL-22 of different periods in patients with RA.Methods:The Patients were divided into different groups according to the RA disease activity score (DAS28),35 patients with active RA and 35 patients with inactive RA .Thirty healthy volunteers were recruited as the normal control.Concentrations of serum IL-22 was measured by Enzyme linked immunosorbent assay (ELISA).The relationship between IL-22 and DAS28 and laboratory data was analyzed at the same time.Results: Compared with the normal control, the levels of serum IL-22 in patients with RA were significantly increased(p<0.05), and there showed the satatistic differences between patients with active RA and inactive RA(p<0.05). The levels of serum IL-22 was positively correlated with 28 joint Disease Activity Score,ESR,CRP and RF(p<0.05).Conclusions:The results suggest that IL-22 may play a role in the pathogenesis of RA and it’s level can be an indicator of disease activity.