中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
11期
1678-1680
,共3页
赵芳%牛勇生%张东晟%尚健静
趙芳%牛勇生%張東晟%尚健靜
조방%우용생%장동성%상건정
肾小球滤过率%胱抑素C%肝硬化
腎小毬濾過率%胱抑素C%肝硬化
신소구려과솔%광억소C%간경화
Glomerular filtration rate%Cystatin C%Liver cirrhosis
目的 探讨肝硬化并发肾功能损害检测血清胱抑素C(Cys-C)与肾功能相关指标间的相关性.方法 129例肝硬化患者根据测得的肾小球滤过功能(GFR)作为评价肾功能的金指标,将患者分为A(肝硬化肾功能正常组)、B(肝硬化并发肾功能不全组)、C(肝硬化继发肾功能衰竭组)三组,比较三组患者Cys-C浓度的差异,并与血清肌酐(Scr)、血β2微球类蛋白(β2-MG)、血肌酐清除率(Ccr)检测相比较.结果 CysC、Scr、β2-MG、Ccr等指标均随着A、B、C三组患者肾功能损害严重程度呈现升高或降低(t=6.65、6.85、6.58、4.54,均P＜0.05);Cys-C、Scr、Ccr、β2-MG等指标异常检出率:A组为31.1％、11.1％、8.9％、26.7％,B组为83.7％、30.2％、34.9％、46.5％,C组为100.0％、85.4％、87.8％、95.1％.结论 血清Cys-C检测是评价肾小球滤过功能的一个灵敏标志物,对肝硬化并发肾功能损害的早期诊断具有临床指导意义.
目的 探討肝硬化併髮腎功能損害檢測血清胱抑素C(Cys-C)與腎功能相關指標間的相關性.方法 129例肝硬化患者根據測得的腎小毬濾過功能(GFR)作為評價腎功能的金指標,將患者分為A(肝硬化腎功能正常組)、B(肝硬化併髮腎功能不全組)、C(肝硬化繼髮腎功能衰竭組)三組,比較三組患者Cys-C濃度的差異,併與血清肌酐(Scr)、血β2微毬類蛋白(β2-MG)、血肌酐清除率(Ccr)檢測相比較.結果 CysC、Scr、β2-MG、Ccr等指標均隨著A、B、C三組患者腎功能損害嚴重程度呈現升高或降低(t=6.65、6.85、6.58、4.54,均P＜0.05);Cys-C、Scr、Ccr、β2-MG等指標異常檢齣率:A組為31.1％、11.1％、8.9％、26.7％,B組為83.7％、30.2％、34.9％、46.5％,C組為100.0％、85.4％、87.8％、95.1％.結論 血清Cys-C檢測是評價腎小毬濾過功能的一箇靈敏標誌物,對肝硬化併髮腎功能損害的早期診斷具有臨床指導意義.
목적 탐토간경화병발신공능손해검측혈청광억소C(Cys-C)여신공능상관지표간적상관성.방법 129례간경화환자근거측득적신소구려과공능(GFR)작위평개신공능적금지표,장환자분위A(간경화신공능정상조)、B(간경화병발신공능불전조)、C(간경화계발신공능쇠갈조)삼조,비교삼조환자Cys-C농도적차이,병여혈청기항(Scr)、혈β2미구류단백(β2-MG)、혈기항청제솔(Ccr)검측상비교.결과 CysC、Scr、β2-MG、Ccr등지표균수착A、B、C삼조환자신공능손해엄중정도정현승고혹강저(t=6.65、6.85、6.58、4.54,균P＜0.05);Cys-C、Scr、Ccr、β2-MG등지표이상검출솔:A조위31.1％、11.1％、8.9％、26.7％,B조위83.7％、30.2％、34.9％、46.5％,C조위100.0％、85.4％、87.8％、95.1％.결론 혈청Cys-C검측시평개신소구려과공능적일개령민표지물,대간경화병발신공능손해적조기진단구유림상지도의의.
Objective To investigate the correlation between serum cystatin C(Cys-C)and renal function in patients with renal damage secondary to cirrhosis.Methods 129 patients with liver cirrhosis were selected,according to the measured glomerular filtration rate (GFR) as the gold standard for evaluation of renal function,patients were divided into group A(cirrhosis with normal renal function),group B(cirrhosis following renal insufficiency),group C (cirrhosis secondary to renal failure).The concentration of Cys-C was compared among three groups,and the serum creatinine(Scr),serum proteins ball micro β2 (β2-MG),creatinine clearance (Ccr) were detected.Results Cys-C,Scr,β2-MG,Ccr and other indicators of A,B,C three groups increased or decreased with the severity of impaired renal function(t =6.65,6.85,6.58,4.54,all P ＜ 0.05).The abnormal detection rates of Cys-C,Scr,Ccr,β2-MG in A group were 31.1％,11.1％,8.9％,26,7％,those in B group were 83.7％,30.2 ％,34.9％,46.5％,those in C group were 100.0％,85.4％,87.8％,95.1％.Conclusion Serum Cys-C concentration is a sensitive marker to evaluate glomerular filtration,it has accurate and reliable clinical significance in the early diagnosis of liver cirrhosis secondary to kidney damage.
