CAJ | 학술논문

目的：探讨血清人附睾蛋白4（H E4）对卵巢癌的诊断价值。方法采用电化学发光免疫分析法测定91例卵巢癌患者（卵巢癌组），69例良性卵巢疾病患者（良性组）及60例健康者（对照组）血清HE4，计算其受试者工作特征（ROC）曲线的曲线下面积（AUC）。结果卵巢癌组患者血清HE4水平[（146．81±81．29） pmol/L]显著高于对照组[（43．16±25．64） pmol/L]及良性组[（59．86±39．87） pmol/L]（P＜0．01）。以血清 HE4≥140 pmol/L 为阳性界值，血清 HE4测定对卵巢癌诊断的敏感性为82．4％（75/91 ），特异性为89．9％（62/69 ），诊断效率为85．6％。浆液性腺癌、子宫内膜样腺癌及其他卵巢癌患者血清 H E4水平显著高于黏液性腺癌（P＜0．01）。Ⅲ、Ⅳ期卵巢癌患者血清HE4水平明显高于Ⅰ、Ⅱ期（P＜0．01）。结论 HE4测定对卵巢癌的辅助诊断具有临床价值。
목적：탐토혈청인부고단백4（H E4）대란소암적진단개치。방법채용전화학발광면역분석법측정91례란소암환자（란소암조），69례량성란소질병환자（량성조）급60례건강자（대조조）혈청HE4，계산기수시자공작특정（ROC）곡선적곡선하면적（AUC）。결과란소암조환자혈청HE4수평[（146．81±81．29） pmol/L]현저고우대조조[（43．16±25．64） pmol/L]급량성조[（59．86±39．87） pmol/L]（P＜0．01）。이혈청 HE4≥140 pmol/L 위양성계치，혈청 HE4측정대란소암진단적민감성위82．4％（75/91 ），특이성위89．9％（62/69 ），진단효솔위85．6％。장액성선암、자궁내막양선암급기타란소암환자혈청 H E4수평현저고우점액성선암（P＜0．01）。Ⅲ、Ⅳ기란소암환자혈청HE4수평명현고우Ⅰ、Ⅱ기（P＜0．01）。결론 HE4측정대란소암적보조진단구유림상개치。
Objective To investigate the diagnostic value of serum human epididymis protein 4 (HE4 ) for ovarian cancer . Methods Electrochemiluminescence immunoassay was employed to detect the serum HE 4 of 91 patients with ovarian cancer (ovari-an cancer group) ,69 patients with benign ovarian disease(benign group) and 60 healthy people(control group) .Area under the curve(AUC ) of receiver operator characteristic (ROC ) curve for HE4 was calculated .Results Serum HE4 level [(146 .81 ± 81 .29)pmol/L] of patients in ovarian cancer group was significantly higher than those in control group [(43 .16 ± 25 .64) pmol/L] and benign group[(59 .86 ± 39 .87) pmol/L](P<0 .01) .Set serum HE4≥140 pmol/L as positive cutoff value ,the diagnostic sensi-tivity of serum HE4 detection for ovarian cancer was 82 .4% (75/91) ,specificity 89 .9% (62/69) and diagnostic efficiency 85 .6% . Serum HE4 levels of patients with serous adenocarcinoma ,endometrial adenocarcinoma or other ovarian cancer were markedly high-er than that with mucinous adenocarcinoma (P<0 .01) .Serum HE4 levels of patients with stage Ⅲ ,Ⅳ ovarian cancer were obvious-ly higher than those with Ⅰ ,Ⅱ stage(P<0 .01) .Conclusion HE4 detection has clinical value for the auxiliary diagnosis of ovarian cancer .