CAJ | 학술논문

目的：探讨血清胃蛋白酶原（PG）与抗 Hp IgG抗体联合检测对胃溃疡早期筛查的临床意义。方法选择首次确诊胃溃疡的65例患者作为溃疡组，将同期65例健康体检者作为对照组。采用胶乳增强免疫透射比浊法检测其血清 PGⅠ、PGⅡ，并计算PGⅠ/Ⅱ比值（PGR）。采用酶联免疫吸附测定（ELISA）检测受检者血清抗 Hp IgG抗体。结果胃溃疡组患者血清PGⅠ、PGⅡ的平均值分别为（167．14±22．43）、（26．68±11．24） ng/mL ，PGR为8．07 ± 1．19；对照组受检者血清PGⅠ、PGⅡ的平均值分别为（52．15±20．17）、（11．26 ± 7．68） ng/mL ，PGR为3．48±1．92。两组 PGⅠ、PGⅡ及PGR的差异具有统计学意义（ P＜0．05）。溃疡组患者血清抗 Hp IgG抗阳性率为80．5％，显著高于对照组（26．3％）（P＜0．05）。 Hp感染阳性组受检者血清 PGⅠ、PGⅡ及PGR显著高于阴性组（P＜0．05）。结论血清PG与抗 Hp IgG抗体联合检测可作为胃溃疡早期的筛查指标。
목적：탐토혈청위단백매원（PG）여항 Hp IgG항체연합검측대위궤양조기사사적림상의의。방법선택수차학진위궤양적65례환자작위궤양조，장동기65례건강체검자작위대조조。채용효유증강면역투사비탁법검측기혈청 PGⅠ、PGⅡ，병계산PGⅠ/Ⅱ비치（PGR）。채용매련면역흡부측정（ELISA）검측수검자혈청항 Hp IgG항체。결과위궤양조환자혈청PGⅠ、PGⅡ적평균치분별위（167．14±22．43）、（26．68±11．24） ng/mL ，PGR위8．07 ± 1．19；대조조수검자혈청PGⅠ、PGⅡ적평균치분별위（52．15±20．17）、（11．26 ± 7．68） ng/mL ，PGR위3．48±1．92。량조 PGⅠ、PGⅡ급PGR적차이구유통계학의의（ P＜0．05）。궤양조환자혈청항 Hp IgG항양성솔위80．5％，현저고우대조조（26．3％）（P＜0．05）。 Hp감염양성조수검자혈청 PGⅠ、PGⅡ급PGR현저고우음성조（P＜0．05）。결론혈청PG여항 Hp IgG항체연합검측가작위위궤양조기적사사지표。
Objective To investigate the clinical significance of combined detection of serum pepsinogen (PG) and anti-Hp IgG antibody in early screening for gastric ulcer .Methods 65 patients confirmed as gastric ulcer for the first time were selected as ulcer group ,while 65 healthy people in the same period as the control group .Transmission detection using latex enhanced immune nephe-lometry was adopted to detect their serum PG Ⅰ ,PG Ⅱ and the PG Ⅰ /PG Ⅱ ratio (PGR) was calculated .Enzyme-linked immu-nosorbent assay(ELISA) was used to detect serum anti-Hp IgG antibody .Results The average concentration of serum PG Ⅰand PG Ⅱof patients in the ulcer group were (167 .14 ± 22 .43) ,(26 .68 ± 11 .24) ng/mL ,respectively ,and PGR was 8 .07 ± 1 .19 .The average concentration of serum PG Ⅰand PG Ⅱof subjects in the control group were (52 .15 ± 20 .17) ,(11 .26 ± 7 .68) ng/mL ,re-spectively ,and PGR was 3 .48 ± 1 .92 .The differences of PGⅠ ,PGⅡand PGR between the two group showed statistical significance (P<0 .05) .The positive rate of serum anti-Hp IgG antibody of patients in the ulcer group was 80 .5% ,which was obviously higher than that in the control group(26 .3% )(P<0 .05) .The serum PGⅠ ,PGⅡand PGR of subjects in Hp infection positive group were markedly higher than those in the negative group(P<0 .05) .Conclusion Combined detection of serum PG and anti-Hp IgG anti-body may be used as an screening indicators for early gastric ulcer .