中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2014年
11期
25-27
,共3页
重度颅脑损伤%抑酸药物%应激性胃黏膜损伤
重度顱腦損傷%抑痠藥物%應激性胃黏膜損傷
중도로뇌손상%억산약물%응격성위점막손상
Severe traumatic brain injury%Acid-suppressing drugs%Stress induced gastric mucosal injury
目的：观察常规应用抑酸药物对重度颅脑损伤患者并发应激性胃黏膜损害的预防效果。方法选取2010-01-2013-06我院收治的60例重度颅脑损伤患者，依据治疗方法不同将其分为抑酸组和对照组各30例。对照组仅接受重度颅脑损伤基础治疗，抑酸组加用抑酸药物静脉注射。比较2组治疗前后的胃液pH值和红细胞数量、肠鸣音活跃或亢进和大便潜血阳性以及治疗前后血胃泌素水平。结果治疗后抑酸组胃液平均pH值明显高于对照组，胃液红细胞低于对照组（ P＜0.05）；治疗后抑酸组肠鸣音活跃或亢进及大便潜血阳性的发生率分别为23.3％、13.3％，对照组分别为50.0％、36.7％，抑酸组患者明显少于对照组（P＜0.05）；治疗4 d后抑酸组患者血胃泌素水平明显低于对照组（P＜0.05）。结论重度颅脑损伤患者伤后早期常规静脉应用抑酸药物可明显降低胃黏膜损害发生率，建议临床推广应用。
目的：觀察常規應用抑痠藥物對重度顱腦損傷患者併髮應激性胃黏膜損害的預防效果。方法選取2010-01-2013-06我院收治的60例重度顱腦損傷患者，依據治療方法不同將其分為抑痠組和對照組各30例。對照組僅接受重度顱腦損傷基礎治療，抑痠組加用抑痠藥物靜脈註射。比較2組治療前後的胃液pH值和紅細胞數量、腸鳴音活躍或亢進和大便潛血暘性以及治療前後血胃泌素水平。結果治療後抑痠組胃液平均pH值明顯高于對照組，胃液紅細胞低于對照組（ P＜0.05）；治療後抑痠組腸鳴音活躍或亢進及大便潛血暘性的髮生率分彆為23.3％、13.3％，對照組分彆為50.0％、36.7％，抑痠組患者明顯少于對照組（P＜0.05）；治療4 d後抑痠組患者血胃泌素水平明顯低于對照組（P＜0.05）。結論重度顱腦損傷患者傷後早期常規靜脈應用抑痠藥物可明顯降低胃黏膜損害髮生率，建議臨床推廣應用。
목적：관찰상규응용억산약물대중도로뇌손상환자병발응격성위점막손해적예방효과。방법선취2010-01-2013-06아원수치적60례중도로뇌손상환자，의거치료방법불동장기분위억산조화대조조각30례。대조조부접수중도로뇌손상기출치료，억산조가용억산약물정맥주사。비교2조치료전후적위액pH치화홍세포수량、장명음활약혹항진화대편잠혈양성이급치료전후혈위비소수평。결과치료후억산조위액평균pH치명현고우대조조，위액홍세포저우대조조（ P＜0.05）；치료후억산조장명음활약혹항진급대편잠혈양성적발생솔분별위23.3％、13.3％，대조조분별위50.0％、36.7％，억산조환자명현소우대조조（P＜0.05）；치료4 d후억산조환자혈위비소수평명현저우대조조（P＜0.05）。결론중도로뇌손상환자상후조기상규정맥응용억산약물가명현강저위점막손해발생솔，건의림상추엄응용。
Objective To explore the effect of routine use of acid-suppressing drugs on patients with severe traumatic brain injury in the prevention of stress-induced gastric mucosal damage.Methods From January 2010 to June 2013 ,60 patients with severe traumatic brain injury in our hospital were divided into antacid group and control group according to the different meth-ods of treatment ,each group had 30 cases.The control group received only basic treatment for severe traumatic brain injury , antacid group received intravenous injection of acid-suppressing drugs based on basic treatment.pH value and red blood cell count of gastric juice ,active or hyperactive bowel sounds ,and positive cases of fecal occult blood ,serum gastrin levels before and after treatment were compared.Results After treatment ,gastric pH value of the antacid group was significantly higher , red blood cells less than that of the control group (P<0.05).The incidence of active or hyperactive bowel sounds and positive cases of fecal occult blood were 23.3% and 13.3% respectively in the antacid group ,while they were 50.0% and 36.7% in the control group ,the incidence of antacid group was significantly less than that of the control group (P<0.05).Four days after treatment ,serum gastrin of the antacid group was significantly lower than that of the control group (P<0.05).Conclusion Early intravenous injection of antacid drugs can significantly reduce the incidence of gastric mucosal damage after severe brain injury ,it should be recommended to actively use in clinics.
