临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2014年
15期
19-20
,共2页
谷氨酰转肽酶%碱性磷酸酶%腺苷脱氨酶%糖类抗原CA19-9%黄疸
穀氨酰轉肽酶%堿性燐痠酶%腺苷脫氨酶%糖類抗原CA19-9%黃疸
곡안선전태매%감성린산매%선감탈안매%당류항원CA19-9%황달
Gamma-glutamyl transpeptidase%Alkaline phosphatase%Adenosine deaminase%Glucoprotein antigen
目的：探讨血清谷氨酰转肽酶（ GGT）、碱性磷酸酶（ ALP）、腺苷脱氨酶（ ADA）、糖类抗原CA19-9升高程度在黄疸类型鉴别中的价值。方法选取本院2011年1月-2013年10月收治的黄疸患者614例，根据黄疸类型将614位患者分为肝细胞性黄疸组和梗阻性黄疸组，后者又分为良性梗阻性黄疸和恶性梗阻性黄疸两组，分析 GGT、ALP、ADA、CA19-9水平在各组间分布差异。结果 GGT、ALP 值在梗阻性黄疸组中较肝细胞性黄疸组高，差异有统计学意义（P ＜0.05）；ADA 值在肝细胞性黄疸组较对照组与梗阻性黄疸组增高，差异有统计学意义（P＜0.05）；GGT、ALP、CA19-9值在恶性梗阻性黄疸组中较良性梗阻性黄疸组高，差异有统计学意义（ P ＜0.05）。结论 GGT、ALP 显著升高，而 ADA 无明显升高的黄疸考虑梗阻性黄疸；GGT、ALP 轻中度升高，而 ADA 显著升高的黄疸考虑肝细胞性性黄疸；GGT、ALP、CA19-9均显著升高者考虑恶性梗阻性黄疸。
目的：探討血清穀氨酰轉肽酶（ GGT）、堿性燐痠酶（ ALP）、腺苷脫氨酶（ ADA）、糖類抗原CA19-9升高程度在黃疸類型鑒彆中的價值。方法選取本院2011年1月-2013年10月收治的黃疸患者614例，根據黃疸類型將614位患者分為肝細胞性黃疸組和梗阻性黃疸組，後者又分為良性梗阻性黃疸和噁性梗阻性黃疸兩組，分析 GGT、ALP、ADA、CA19-9水平在各組間分佈差異。結果 GGT、ALP 值在梗阻性黃疸組中較肝細胞性黃疸組高，差異有統計學意義（P ＜0.05）；ADA 值在肝細胞性黃疸組較對照組與梗阻性黃疸組增高，差異有統計學意義（P＜0.05）；GGT、ALP、CA19-9值在噁性梗阻性黃疸組中較良性梗阻性黃疸組高，差異有統計學意義（ P ＜0.05）。結論 GGT、ALP 顯著升高，而 ADA 無明顯升高的黃疸攷慮梗阻性黃疸；GGT、ALP 輕中度升高，而 ADA 顯著升高的黃疸攷慮肝細胞性性黃疸；GGT、ALP、CA19-9均顯著升高者攷慮噁性梗阻性黃疸。
목적：탐토혈청곡안선전태매（ GGT）、감성린산매（ ALP）、선감탈안매（ ADA）、당류항원CA19-9승고정도재황달류형감별중적개치。방법선취본원2011년1월-2013년10월수치적황달환자614례，근거황달류형장614위환자분위간세포성황달조화경조성황달조，후자우분위량성경조성황달화악성경조성황달량조，분석 GGT、ALP、ADA、CA19-9수평재각조간분포차이。결과 GGT、ALP 치재경조성황달조중교간세포성황달조고，차이유통계학의의（P ＜0.05）；ADA 치재간세포성황달조교대조조여경조성황달조증고，차이유통계학의의（P＜0.05）；GGT、ALP、CA19-9치재악성경조성황달조중교량성경조성황달조고，차이유통계학의의（ P ＜0.05）。결론 GGT、ALP 현저승고，이 ADA 무명현승고적황달고필경조성황달；GGT、ALP 경중도승고，이 ADA 현저승고적황달고필간세포성성황달；GGT、ALP、CA19-9균현저승고자고필악성경조성황달。
Objective To investigate the value of serum GGT,ALP,ADA and CA19 - 9 in the diagnosis of jaun-dice. Methods 614 cases with jaundice were admitted to our hospital from January 2011 to October 2013,were divided into hepatocellular and obstructive jaundice group according to the type,and the patients in obstructive jaundice group were divided into benign obstructive jaundice group and malignant obstructive jaundice group. The distribution of serum GGT,ALP,ADA and CA19 - 9 in each group were analyzed. Results Compared with hepatocellular jaundice group,the serum level of GGT and ALP were higher in obstructive jaundice group,the differences were statistically significant(P < 0. 05);Compared with obstruc-tive jaundice group,the serum level of ADA was higher in hepatocellular Jaundice group,the difference was statistically signifi-cant(P < 0. 05);Compared with benign obstructive jaundice group,the serum levels of GGT,ALP and CA19 - 9 were higher in malignant obstructive jaundice group,the differences were statistically significant(P < 0. 05). Conclusion Jaundice with marked elevation of serum GGT and ALP while no significant elevation of serum ADA is considered as obstructive jaundice;Jaundice with marked elevation of serum ADA while mild elevation of serum GGT and ALP are considered as hepatocellular jaun-dice;Jaundice with marked elevation of serum GGT,ALP and CA19 - 9 are considered as malignant obstructive jaundice.
