CAJ | 학술논문

咪唑啉I2受体是一种非G蛋白偶联受体，其生理功能及临床意义目前尚不十分清楚。近年大量研究表明I2受体通过相关配体介导多种行为学效应。激活咪唑啉I2受体可能产生镇痛、抗抑郁、调节阿片受体功能、神经元保护等多种药理学作用。该文着重介绍了I2受体的分布、细胞定位、分子结构、信号转导、内源性配体和选择性配体及其相关神经药理学效应的研究进展。
미서람I2수체시일충비G단백우련수체，기생리공능급림상의의목전상불십분청초。근년대량연구표명I2수체통과상관배체개도다충행위학효응。격활미서람I2수체가능산생진통、항억욱、조절아편수체공능、신경원보호등다충약이학작용。해문착중개소료I2수체적분포、세포정위、분자결구、신호전도、내원성배체화선택성배체급기상관신경약이학효응적연구진전。
Imidazoline-I2 receptor is a group of non-G protein-coupled receptors (GPCR). Its physiological function and clinical significance remains elusive. Accumulating evidence has implicated the imidazoline-I2 receptors in a wide range of behavioral effects, including analgesia, antidepressant-like effects, modulation ofμopioid receptors and neuroprotection. Here, we provided an updated overview of its location, molecular structure, signal transduction, endogenous ligands, synthetic ligands and related neuropharmacological effects.