CAJ | 학술논문

吸入麻醉药因其安全、可靠、稳定、易于控制等特性广泛应用于临床全麻手术中。近年来研究表明，吸入麻醉药可以通过减轻细胞损伤，降低梗死面积等方式在分子和细胞水平对脑、心脏、肝脏、肾脏等器官的缺血再灌注损害起到一定的保护作用。吸入麻醉药可通过激活离子通道、抑制细胞凋亡、基因调控、减少自由基产生等多种途径发挥保护作用。该文综述了吸入麻醉药对机体脏器的保护作用及其机制。
흡입마취약인기안전、가고、은정、역우공제등특성엄범응용우림상전마수술중。근년래연구표명，흡입마취약가이통과감경세포손상，강저경사면적등방식재분자화세포수평대뇌、심장、간장、신장등기관적결혈재관주손해기도일정적보호작용。흡입마취약가통과격활리자통도、억제세포조망、기인조공、감소자유기산생등다충도경발휘보호작용。해문종술료흡입마취약대궤체장기적보호작용급기궤제。
Volatile anesthetics are widely used in general anesthesia because of their favorable properties,such as safety,reliability,stability and easily controllable. Recent studies have revealed that volatile anesthetics have protective effects on a variety of organs such as brain,heart,liver,kidney after ischemia/reperfusion at molecular and cellular levels by reducing cell damages and infarction area. In this review,we summarize the protective effects of volatile anesthetics on the organs and discuss the mechanisms of the protective action. Volatile anesthetic can play protective roles by activating ion channels,inhibiting cell apoptosis,regulating genes, reducing the free radicals. This article lays a theoretical foundation for the reasonable application of anesthetics during operations and reducing ischemia reperfusion injury.