CAJ | 학술논문

目的观察泮托拉唑治疗老年非甾体类抗炎药(NSAIDs)相关消化性溃疡出血的临床效果.方法随机选取在我院就诊的老年NSAIDs相关消化性溃疡出血患者100例,分为观察组和对照组.对照组使用法莫替丁静脉滴注,观察组使用泮托拉唑静脉滴注.对比两组止血效果、再出血及不良反应情况.结果经一个疗程治疗,观察组止血总有效率为94％,对照组总有效率为82％,两组止血效果差异有统计学意义(P＜0.05)；观察组再出血率为6％,显著低于对照组的22％,差异有统计学意义,P＜ 0.05.结论泮托拉唑治疗老年NSAIDs相关消化性溃疡出血安全有效,并发症少.
목적 관찰반탁랍서치료노년비치체류항염약(NSAIDs)상관소화성궤양출혈적림상효과.방법 수궤선취재아원취진적노년NSAIDs상관소화성궤양출혈환자100례,분위관찰조화대조조.대조조사용법막체정정맥적주,관찰조사용반탁랍서정맥적주.대비량조지혈효과、재출혈급불량반응정황.결과 경일개료정치료,관찰조지혈총유효솔위94％,대조조총유효솔위82％,량조지혈효과차이유통계학의의(P＜0.05)；관찰조재출혈솔위6％,현저저우대조조적22％,차이유통계학의의,P＜ 0.05.결론 반탁랍서치료노년NSAIDs상관소화성궤양출혈안전유효,병발증소.
Objective To observe the clinical efficacy of pantoprazole in the treatnent of NSAIDs-related bleeding peptic ulcers in elderly patients.Methods 100 elderly patients with NSAIDs-related bleeding peptic ulcers were randomly selected and then divided into study group and control group.The control group received intravenous infusions of famotidine,and the study group received intravenous infusions of pantoprazole.The effect of hemostasis,re-bleeding,and adverse reactions were compared between the two groups.Results After a course of treatment,the total effectiveness rate for hemostasis was 94％ in the study group and 82％ in the control group,with a statistical difference (P＜0.05).The rate of re-bleeding rate was significantly lower in the study group than in the control group (6％ vs.22％,P＜0.05).Conclusions Pantoprazole is safe and effective in the treatment of elderly patients with NSAIDs-related bleeding peptic ulcer.