CAJ | 학술논문

目的：系统评价中国人群HLA-B 基因多态性与HIV 易感性及疾病进程的关系。方法全面检索查找已发表的相关病例对照研究及横断面研究，并追溯其参考文献，按纳入和排除标准进行文献筛选、资料提取及质量评价，使用RevMan 4．2及SAS 9．1．3软件进行统计分析。结果共纳入11篇文献。6篇为HLA-B基因与HIV疾病进程相关性研究，Meta 分析结果显示，HLA-B*27、HLA-B*51和HLA-B*58为HIV/AIDS 病程进展的保护性基因，合并比值比分别为0．49、0．61和0．65。 HLA-B*35为HIV/AIDS 病程进展的危险基因，合并比值比为1．87。5篇为HLA-B基因与HIV易感性的关联性研究，Meta分析结果显示，HLA-B*37和HLA-B*46为HIV感染的易感性基因，合并比值比分别为1．62和1．19。 HLA-B*39为 HIV 感染保护性基因，合并比值比为0．67。结论 HLA-B*27、HLA-B*51和HLA-B*58可能延缓而 HLA-B*35可能加速中国人群 HIV 感染后的疾病进程；HLA-B*39可能降低而HLA-B*37和HLA-B*46可能增高中国人群对HIV感染的易感性。
목적：계통평개중국인군HLA-B 기인다태성여HIV 역감성급질병진정적관계。방법전면검색사조이발표적상관병례대조연구급횡단면연구，병추소기삼고문헌，안납입화배제표준진행문헌사선、자료제취급질량평개，사용RevMan 4．2급SAS 9．1．3연건진행통계분석。결과공납입11편문헌。6편위HLA-B기인여HIV질병진정상관성연구，Meta 분석결과현시，HLA-B*27、HLA-B*51화HLA-B*58위HIV/AIDS 병정진전적보호성기인，합병비치비분별위0．49、0．61화0．65。 HLA-B*35위HIV/AIDS 병정진전적위험기인，합병비치비위1．87。5편위HLA-B기인여HIV역감성적관련성연구，Meta분석결과현시，HLA-B*37화HLA-B*46위HIV감염적역감성기인，합병비치비분별위1．62화1．19。 HLA-B*39위 HIV 감염보호성기인，합병비치비위0．67。결론 HLA-B*27、HLA-B*51화HLA-B*58가능연완이 HLA-B*35가능가속중국인군 HIV 감염후적질병진정；HLA-B*39가능강저이HLA-B*37화HLA-B*46가능증고중국인군대HIV감염적역감성。
Objective To evaluate the association between gene of HLA-B and HIV infection and disease progression in Chinese population. Methods Electronic searches were conducted roundly to find the case-control studies and cross-sectional studies on the association between HLA-B gene polymorphism and HIV infection or disease course. References of relevant studies were also retrieved. The references was screened with the inclusion and exclusion criteria, and then data were extracted and methodological quality of the studies was judged. Statistical analysis was carried out with RevMan 4.2 and SAS 9.1.3. Results 11 studies were included lastly. 6 studies were about the association between gene of HLA-B and disease progression in Chinese HIV infected population , meta-analysis results revealed that the pooled OR of HLA-B*27, HLA-B*51, and HLA-B*58 were 0.49, 0.61 and 0.65 respectively, and they acted as the protective genes in the HIV/AIDS progression. HLA-B*35(pooled OR=1.87) was the risk gene in the HIV/AIDS progression. 5 studies were about the association between gene of HLA-B and HIV infection in Chinese population, meta-analysis results revealed that the pooled OR of HLA-B*37 and HLA-B*46 were 1.62 and 1.19, and they acted as the susceptible genes in HIV infection. HLA-B*39(pooled OR=0.67) was the protective gene in HIV infection. Conclusions HLA-B*27, HLA-B*51 and HLA-B*58 may act as the protective genes in HIV infected disease progression , and HLA-B*35 may act as the susceptible gene in HIV infected disease progression;HLA-B*39 may act as the protective gene in HIV infection. HLA-B*37 and HLA-B*46 may act as the susceptible genes in HIV infection.