中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2014年
27期
21-23
,共3页
哮喘%骨化二醇%免疫球蛋白E
哮喘%骨化二醇%免疫毬蛋白E
효천%골화이순%면역구단백E
Asthma%Calcifediol%Immunoglobulin E
目的 探讨25-羟维生素D3[25-(OH)D3]及总IgE (TIgE)在儿童支气管哮喘发病过程中的作用.方法 选取22例支气管哮喘患儿(支气管哮喘组)及20例健康体检儿童(对照组),测定比较两组血清25-(OH)D3及TIgE水平.结果 支气管哮喘组血清25-(OH)D3为(23.64±3.89)μg/L,明显低于对照组的(35.82±4.37)μg/L,差异有统计学意义(P＜0.05).支气管哮喘组血清TIgE为(208.62±32.59) kU/L,明显高于对照组的(73.84±18.86) kU/L,差异有统计学意义(P＜0.05).支气管哮喘组血清25-(OH)D3与血清TIgE呈负相关(r=-0.832,P＜ 0.01),对照组血清25-(OH)D3与血清TIgE无相关性(r=-0.038,P＞0.05).结论 25-(OH)D3的缺乏与变态反应密切相关,可能在支气管哮喘发病中有重要作用,监测其水平变化有助于评估支气管哮喘患儿的病情.
目的 探討25-羥維生素D3[25-(OH)D3]及總IgE (TIgE)在兒童支氣管哮喘髮病過程中的作用.方法 選取22例支氣管哮喘患兒(支氣管哮喘組)及20例健康體檢兒童(對照組),測定比較兩組血清25-(OH)D3及TIgE水平.結果 支氣管哮喘組血清25-(OH)D3為(23.64±3.89)μg/L,明顯低于對照組的(35.82±4.37)μg/L,差異有統計學意義(P＜0.05).支氣管哮喘組血清TIgE為(208.62±32.59) kU/L,明顯高于對照組的(73.84±18.86) kU/L,差異有統計學意義(P＜0.05).支氣管哮喘組血清25-(OH)D3與血清TIgE呈負相關(r=-0.832,P＜ 0.01),對照組血清25-(OH)D3與血清TIgE無相關性(r=-0.038,P＞0.05).結論 25-(OH)D3的缺乏與變態反應密切相關,可能在支氣管哮喘髮病中有重要作用,鑑測其水平變化有助于評估支氣管哮喘患兒的病情.
목적 탐토25-간유생소D3[25-(OH)D3]급총IgE (TIgE)재인동지기관효천발병과정중적작용.방법 선취22례지기관효천환인(지기관효천조)급20례건강체검인동(대조조),측정비교량조혈청25-(OH)D3급TIgE수평.결과 지기관효천조혈청25-(OH)D3위(23.64±3.89)μg/L,명현저우대조조적(35.82±4.37)μg/L,차이유통계학의의(P＜0.05).지기관효천조혈청TIgE위(208.62±32.59) kU/L,명현고우대조조적(73.84±18.86) kU/L,차이유통계학의의(P＜0.05).지기관효천조혈청25-(OH)D3여혈청TIgE정부상관(r=-0.832,P＜ 0.01),대조조혈청25-(OH)D3여혈청TIgE무상관성(r=-0.038,P＞0.05).결론 25-(OH)D3적결핍여변태반응밀절상관,가능재지기관효천발병중유중요작용,감측기수평변화유조우평고지기관효천환인적병정.
Objective To study the effect of the serum levels of 25-hydroxyvitamin D3 [25-(OH)D3] and total IgE (TIgE) in pathogenesis of the children bronchial asthma.Methods Twenty-two children with bronchial asthma (bronchial asthma group) and 20 healthy children (control group) were selected.The serum levels of 25-(OH)D3 and TIgE in the children of 2 groups were detected.Results The level of serum 25-(OH)D3 in bronchial asthma group was significantly lower than that in control group [(23.64 ± 3.89)μ g/L vs.(35.82 ± 4.37) μ g/L],there was statistical difference (P ＜ 0.05).The level of serum TIgE in bronchial asthma group was significantly higher than that in control group [(208.62 ± 32.59) kU/L vs.(73.84 ± 18.86) kU/L],there was statistical difference (P ＜ 0.05).There was negative correlation between the level of serum 25-(OH)D3 and TIgE in bronchial asthma group (r =-0.832,P ＜ 0.01),but there was no correlation between the level of serum 25-(OH)D3 and TIgE in control group (r =-0.038,P ＞0.05).Conclusions The lack of 25-(OH)D3 may be associated with allergy and childhood bronchial asthma.By monitor the levels of 25-(OH)D3 and TIgE may assess condition of childhood bronchial asthma.
