CAJ | 학술논문

目的：探讨血清甲胎蛋白异质体3（AFP-L3）在原发性肝癌早期筛查中的作用。方法以装有耦联小扁豆凝集素（LCA）的微量离心柱分离慢性肝病、原发性肝癌共116例患者AFP-L3，用化学发光方法检测分离前后AFP-L3，计算AFP-L3在AFP中的含量比例。结果原发性肝癌组AFP-L3含量比例均值[（36．89±2．13）％]，与慢性肝病组[（7．45±2．32）％]相比差异有统计学意义（ P＜0．01）。结论微量离心柱法测定AFP-L3的含量在原发性肝癌的早期筛查中具有重要意义。
목적：탐토혈청갑태단백이질체3（AFP-L3）재원발성간암조기사사중적작용。방법이장유우련소편두응집소（LCA）적미량리심주분리만성간병、원발성간암공116례환자AFP-L3，용화학발광방법검측분리전후AFP-L3，계산AFP-L3재AFP중적함량비례。결과원발성간암조AFP-L3함량비례균치[（36．89±2．13）％]，여만성간병조[（7．45±2．32）％]상비차이유통계학의의（ P＜0．01）。결론미량리심주법측정AFP-L3적함량재원발성간암적조기사사중구유중요의의。
Objective To explore the value of serum alpha-fetoprotein (AFP-L3) in early screening of primary liver cancer. Methods Lentil lectin coupled with ( LCA) micro-centrifuge column was separated to obtain AFP-L3 from 116 cases of chronic liver disease and primary liver cancer .AFP before separation and AFP-L3 after separation were detected with chemoluminescence , and their levels were then calculated .Results Statistical differences could be seen in the average value of AFP-L3 between the patients with pri-mary liver cancer and patients with chronic liver disease (P<0.01).Conclusion The level detected with micro-centrifuge column was of importance in early screening of primary liver cancer .