南通大学学报(医学版)
南通大學學報(醫學版)
남통대학학보(의학판)
JOURNAL OF NANTONG UNIVERSITY(MEDICAL SCIENCES)
2014年
3期
159-162
,共4页
田觅%邹晓平%陈磊%魏威%叶静
田覓%鄒曉平%陳磊%魏威%葉靜
전멱%추효평%진뢰%위위%협정
重症急性胰腺炎%生态免疫营养%肠道营养%胃肠外营养%肾损害%猪
重癥急性胰腺炎%生態免疫營養%腸道營養%胃腸外營養%腎損害%豬
중증급성이선염%생태면역영양%장도영양%위장외영양%신손해%저
severe acute pancreatitis%ecoimmunonutrition%enteral nutrition%parenteral nutrition%kidney injury%pig
目的:观察不同营养支持对重症急性胰腺炎(severe acute pancreatitis,SAP)猪的肾损害的影响。方法:采用胰管内注射牛磺胆酸钠和胰蛋白酶的方法诱导猪SAP模型;将SAP模型动物随机分为3组,分别为肠外营养组(par-enteral nutrition,PN)、肠内要素营养组(elemental enteral nutrition,EEN)和肠内免疫微生态营养组(enteral ecoimmunonutri-tion,EIN),分别进行相应的营养8 d。动态检测各组血尿素氮(blood urea nitrogen,BUN)、肌酐(creatinine,Cr)。营养8 d后剖腹测定肾脏丙二醛(malondialdehyde, MDA)含量及超氧化物歧化酶(supemxidedismutase, SOD)活力,观察肾脏组织病理学改变,进行病理评分。结果:营养支持8 d后,EIN组的BUN、Cr均低于PN组和EEN组(均P<0.05)。营养8 d后,EIN组的肾脏 MDA 含量及肾脏病理学评分均低于 PN 组和 EEN 组,而肾脏 SOD 活力则明显高于 PN 组和 EEN 组(均P<0.05)。结论:早期EIN可减轻SAP时的肾损害。
目的:觀察不同營養支持對重癥急性胰腺炎(severe acute pancreatitis,SAP)豬的腎損害的影響。方法:採用胰管內註射牛磺膽痠鈉和胰蛋白酶的方法誘導豬SAP模型;將SAP模型動物隨機分為3組,分彆為腸外營養組(par-enteral nutrition,PN)、腸內要素營養組(elemental enteral nutrition,EEN)和腸內免疫微生態營養組(enteral ecoimmunonutri-tion,EIN),分彆進行相應的營養8 d。動態檢測各組血尿素氮(blood urea nitrogen,BUN)、肌酐(creatinine,Cr)。營養8 d後剖腹測定腎髒丙二醛(malondialdehyde, MDA)含量及超氧化物歧化酶(supemxidedismutase, SOD)活力,觀察腎髒組織病理學改變,進行病理評分。結果:營養支持8 d後,EIN組的BUN、Cr均低于PN組和EEN組(均P<0.05)。營養8 d後,EIN組的腎髒 MDA 含量及腎髒病理學評分均低于 PN 組和 EEN 組,而腎髒 SOD 活力則明顯高于 PN 組和 EEN 組(均P<0.05)。結論:早期EIN可減輕SAP時的腎損害。
목적:관찰불동영양지지대중증급성이선염(severe acute pancreatitis,SAP)저적신손해적영향。방법:채용이관내주사우광담산납화이단백매적방법유도저SAP모형;장SAP모형동물수궤분위3조,분별위장외영양조(par-enteral nutrition,PN)、장내요소영양조(elemental enteral nutrition,EEN)화장내면역미생태영양조(enteral ecoimmunonutri-tion,EIN),분별진행상응적영양8 d。동태검측각조혈뇨소담(blood urea nitrogen,BUN)、기항(creatinine,Cr)。영양8 d후부복측정신장병이철(malondialdehyde, MDA)함량급초양화물기화매(supemxidedismutase, SOD)활력,관찰신장조직병이학개변,진행병리평분。결과:영양지지8 d후,EIN조적BUN、Cr균저우PN조화EEN조(균P<0.05)。영양8 d후,EIN조적신장 MDA 함량급신장병이학평분균저우 PN 조화 EEN 조,이신장 SOD 활력칙명현고우 PN 조화 EEN 조(균P<0.05)。결론:조기EIN가감경SAP시적신손해。
Objective: To evaluate the effect of enteral ecoimmunonutrition(EIN) on kidney injury in pig with severe acute pancreatitis. Methods: Swine model of SAP was induced by injecting 5% sodium taurecholate into the pancreatic duel. The pigs were randomly divided into three groups, parenteral nutrition(PN) group, elemental enteral nutrition(EEN) group, and EIN group after induction of SAP. Each group was treated with abovementioned nutrition supports for eight days , respectively. The serum blood urea nitrogen and creatinine were determined dynamically. All the pigs were sacrificed after the 8-day nutri-tion support, and renal malondialdehyde(MDA), supemxidedismutase(SOD) were measured. The histopathological changes of kidney were examined. Results: After 8 days of nutrition support, BUN and Cr levels in EIN group were significantly lower than those in TPN group and EEN group(all P<0.05). In addition, the renal concentration of MDA and renal histopathological scores were lower than those of PN group and EEN group, while renal SOD activity was higher in EIN group than those in the other 2 groups(P<0.05). Conclusion:Early enteral EIN is superior to PN and EEN could alleviate renal injury in SAP.