CAJ | 학술논문

目的：探讨血清中肿瘤标记物CEA、CYFRA21-1、NSE和SCCAg进行单项和联合检测，对肺癌的诊断价值。方法选取行肿瘤标记物检测的肺癌患者80例，健康体检者80例，设为观察组和对照组；采用电化学发光免疫技术对其进行血清肿瘤标记物CEA、CYFRA21-1、NSE和SCCAg含量检测。结果观察组患者血清肿瘤标记物CEA、CYFRA21-1、NSE和SCCAg含量均高于对照组，差异统计学意义（P＜0．05）。观察组CEA、CYFRA21-1、NSE和SCCAg阳性检测率分别为52．7％、67．4％、63．5％、31．9％；血清四项肿瘤标记物联合检测的阳性率为89．3％，对肺癌诊断灵敏度明显优于单项检测（P＜0．05）；进行联合检测时对腺癌的检出率为71．4％，小细胞癌为75．0％，鳞状细胞癌为90．2％，均明显高于肿瘤标记物各项单项检出率。结论肿瘤标记物CEA、CYFRA21-1、NSE和SCCAg联合检测阳性检出率明显高于单项检测，更有利于肺癌的诊断。
목적：탐토혈청중종류표기물CEA、CYFRA21-1、NSE화SCCAg진행단항화연합검측，대폐암적진단개치。방법선취행종류표기물검측적폐암환자80례，건강체검자80례，설위관찰조화대조조；채용전화학발광면역기술대기진행혈청종류표기물CEA、CYFRA21-1、NSE화SCCAg함량검측。결과관찰조환자혈청종류표기물CEA、CYFRA21-1、NSE화SCCAg함량균고우대조조，차이통계학의의（P＜0．05）。관찰조CEA、CYFRA21-1、NSE화SCCAg양성검측솔분별위52．7％、67．4％、63．5％、31．9％；혈청사항종류표기물연합검측적양성솔위89．3％，대폐암진단령민도명현우우단항검측（P＜0．05）；진행연합검측시대선암적검출솔위71．4％，소세포암위75．0％，린상세포암위90．2％，균명현고우종류표기물각항단항검출솔。결론종류표기물CEA、CYFRA21-1、NSE화SCCAg연합검측양성검출솔명현고우단항검측，경유리우폐암적진단。
Objective To analyze and explore the diagnositic value and clinical effect of lung cancer through single detection and combined detection.Methods 80 cases of lung cancer patients and 80 cases of healthy patients who did tumor markers detection in our hospital from January,2012 to January,2013 were analyzed retrospectively,di-vided them into experimental group and control group.The content of serum tumor markers were CEA,CYFRA21 -1, NSE and SCCAg by electrochemiluminescence immunoassay.Results The serum tumor markers CEA,CYFRA21 -1 ,NSE and SCCAg of experimental group was higher than control group,the difference has statistic significance(P<0.05).The tumor markers of experimental group was more sensitive to the diagnosis of lung cancer,the positive detec-tion rates of CEA,CYFRA21 -1,NSE and SCCAg were 52.7%、67.4%、63.5%、31.9%;the positive rate of four serum tumor markers combined detection was 89.3%,the diagnosis sensitivity of lung cancer was significantly better than single detection(P<0.05);the detection rate of combined detection for cancer was 71.4%,for small cell carci-noma was 75.0%,squamous cell carcinoma was 90.2%,which were significantly higher than those of the single tumor markers detection rate.Conclusion The positive rate of combined tumor markers CEA,CYFRA21 -1,NSE and SCCAg detection is significantly higher than that of single detection,which is more conductive to timely diagnosis of lung cancer,to identify pathological type of lung cancer.