CAJ | 학술논문

干细胞移植是治疗心肌梗死的新策略，MRI既可以提供心血管详细解剖结构和功能信息，还能有效地示踪细胞，从而更好的监测和观察细胞移植的情况。目前常规的示踪方法是通过超顺磁性氧化铁颗粒直接标记细胞，这种示踪方式可以确定细胞移植的在体内的分布，然而其特异性较差，不能反映细胞的存活情况。而MRI报告基因成像在一定程度上避免了传统超顺磁性氧化铁直接标记细胞示踪法的劣势，可以验证细胞的存活，通过这种方法可以更深入的认识移植细胞的存活和分化情况。
간세포이식시치료심기경사적신책략，MRI기가이제공심혈관상세해부결구화공능신식，환능유효지시종세포，종이경호적감측화관찰세포이식적정황。목전상규적시종방법시통과초순자성양화철과립직접표기세포，저충시종방식가이학정세포이식적재체내적분포，연이기특이성교차，불능반영세포적존활정황。이MRI보고기인성상재일정정도상피면료전통초순자성양화철직접표기세포시종법적열세，가이험증세포적존활，통과저충방법가이경심입적인식이식세포적존활화분화정황。
Stem cell transplantation has the potential to treat myocardial infarction. MRI is emerging as a robust tool to provide anatomical and functional information of patient with cardiovascular disease, but also plays an important role in tracing graft cells. SPIO is one of the most widely used probes, which can identify the graft site accurately. However, the presence of SPIO cannot guarantee the survival of the stem cells and this limits its use. The MRI reporter gene imaging technique can fill this gap to access the survival information of the grafted cells and help researchers to achieve a higher level of understanding of the fate of the cell.