CAJ | 학술논문

通过查阅近几年相关的文献资料，结合工作实践经验，以小剂量片剂甲基斑蝥胺片为例，对制粒过程中原辅料细度、粘合剂选择、主辅料混合、温度控制、颗粒质量等关键环节进行分析总结。为保证小剂量片剂的含量均匀度符合《中国药典》要求，原辅料细度要适宜、主辅料混合必须均匀，要有足够的时间混合、粘合剂的选择要科学合理、干燥方法要切合实际，以及颗粒质量必须符合工艺要求。
통과사열근궤년상관적문헌자료，결합공작실천경험，이소제량편제갑기반모알편위례，대제립과정중원보료세도、점합제선택、주보료혼합、온도공제、과립질량등관건배절진행분석총결。위보증소제량편제적함량균균도부합《중국약전》요구，원보료세도요괄의、주보료혼합필수균균，요유족구적시간혼합、점합제적선택요과학합리、간조방법요절합실제，이급과립질량필수부합공예요구。
This study was aimed to introduce the key link in the process of granulating of small-dose methyl can-tharis amine tablets. Combined with practical experiences in daily jobs, related literatures in recent years from the fineness of raw materials, choice of main materials mixing, selection of adhesive, drying methods and grain quality were analyzed. The results showed that in order to ensure the content uniformity of small-dose tablets and conform to requirements of the Chinese Pharmacopoeia, the fineness of raw materials should be appropriate; the main supple-mentary material must be evenly mixed with enough time; the choice of adhesive should be scientific and reasonable;the drying method should be practical; and the grain quality should meet the technological requirements.