CAJ | 학술논문

本文概述了三大经典代表斑蝥类化合物的来源和物化性质，综述了其合成策略和基本合成路线。随后着重综述了斑蝥素和去甲斑蝥素及其衍生物的基本概况，及其近年来在抗肿瘤方面的研究进展，特别是其与抗癌机理密切相关的特异性结合酶，丝/苏氨酸蛋白磷酸酯酶（PP）中PP1、PP2A和PP2B的抑制活性和选择性的构效关系。总结了斑蝥类新型生物活性小分子的设计和发展方向。
본문개술료삼대경전대표반모류화합물적래원화물화성질，종술료기합성책략화기본합성로선。수후착중종술료반모소화거갑반모소급기연생물적기본개황，급기근년래재항종류방면적연구진전，특별시기여항암궤리밀절상관적특이성결합매，사/소안산단백린산지매（PP）중PP1、PP2A화PP2B적억제활성화선택성적구효관계。총결료반모류신형생물활성소분자적설계화발전방향。
This study was aimed to summarize main-bone structure of cantharidin-based small molecules and facts about three typical candidates including its origin, physical-chemical properties and general synthetic approaches. Basic chemical and pharmacological information as well as development of anti-cancer activities, which were related to cantharidin, norcantharidin and their analogues were reviewed, especially the relationship between the structures and their inhibitory activity and selectivity of serine-threonine protein phosphatases PP1, PP2A and PP2B in cancer treatment. The designs and developments of new biological cantharidin-based small molecules were also reviewed.