CAJ | 학술논문

目的：通过制备刺五加叶总黄酮固体分散体，提高其生物利用度。方法：以 PEG4000、PEG6000、F68、PVPK30为载体材料制备4种不同的固体分散体，筛选最优载体材料，并考察载体用量对溶出度的影响。以芦丁为对照品，亚硝酸钠-硝酸铝-氢氧化钠为显色体系，用紫外分光光度计在500 nm处测定吸光度，考察各比例固体分散体的体外溶出特性。结果：与原料药相比，以PVPK30为载体材料制得的固体分散体体外释放速率明显提高，并且累积释放度也明显增加。结论：固体分散体能显著提高药物在水中的体外释放度。
목적：통과제비자오가협총황동고체분산체，제고기생물이용도。방법：이 PEG4000、PEG6000、F68、PVPK30위재체재료제비4충불동적고체분산체，사선최우재체재료，병고찰재체용량대용출도적영향。이호정위대조품，아초산납-초산려-경양화납위현색체계，용자외분광광도계재500 nm처측정흡광도，고찰각비례고체분산체적체외용출특성。결과：여원료약상비，이PVPK30위재체재료제득적고체분산체체외석방속솔명현제고，병차루적석방도야명현증가。결론：고체분산체능현저제고약물재수중적체외석방도。
This study was aimed to prepare solid dispersions of Acanthopanax leaves total flavonoids in order to im-prove its bioavailability. PEG4000, PEG6000, F68, PVPK30 were used as carrier materials in the preparation of four different types of solid dispersion to screen the best type of carrier material and evaluate the amount of carrier mate-rial and its influence on the drug dissolution. Rutin was used as reference substance. NaNO2-Al(NO3)3-NaOH was used as the color system, with a UV spectrophotometer measured absorbance at 500 nm. The dissolution characteris-tics of different proportions of solid dispersions were examined in vitro. The results showed that compared with raw material, the in vitro drug release rate with PVPK30 as carrier material in the obtained solid dispersion of the pro-portion of the raw material was significantly improved, and the cumulative release rate was also increased significant-ly. It was concluded that the solid dispersion prepared by solvent method significantly improved in vitro drug release in water.