CAJ | 학술논문

目的：研究表明从菠萝叶中制备的总酚类成分具有抗氧化和调血脂作用。由于其灌胃后吸收较快，血中5 min即达峰值，因此本文通过急性糖脂负荷实验观察菠萝叶酚对糖脂吸收的影响。方法：利用小鼠单次灌胃建立糖脂负荷模型，观察给药后不同时间对餐后血糖、血脂和小肠脂肪酶的变化。结果：菠萝叶酚在一定程度上能够抑制甘油三酯和葡萄糖的吸收。在给药30 min后未见到明显的作用，但此时正常小鼠小肠脂肪酶活性受到明显抑制，并且对高脂所致小肠脂肪酶活性下降有一定的解抑制作用。结论：提示菠萝叶酚的抑制脂类吸收可能与脂肪酶活性有关；其对于餐后高糖高脂吸收的有一定调控作用。
목적：연구표명종파라협중제비적총분류성분구유항양화화조혈지작용。유우기관위후흡수교쾌，혈중5 min즉체봉치，인차본문통과급성당지부하실험관찰파라협분대당지흡수적영향。방법：이용소서단차관위건립당지부하모형，관찰급약후불동시간대찬후혈당、혈지화소장지방매적변화。결과：파라협분재일정정도상능구억제감유삼지화포도당적흡수。재급약30 min후미견도명현적작용，단차시정상소서소장지방매활성수도명현억제，병차대고지소치소장지방매활성하강유일정적해억제작용。결론：제시파라협분적억제지류흡수가능여지방매활성유관；기대우찬후고당고지흡수적유일정조공작용。
This article was aimed to study the antioxidant and antihyperlipidemic effect of total phenolic composition prepared from pineapple (A nanas comosus L.) leave. It had a rapid absorption after intragastric administration and the principle ingredient, p-coumaric acid, reached the peak concentration after 5 minutes of administration. The mice model with single intragastric administration of lipid and glucose were used in the observation of changes on postprandial glucose, lipid and intestinal lipase at different time points after drug administration. The results showed that phenols of pineapple leave can inhibit triglyceride and glucose absorption in certain extent. No significant effect was observed on inhibition at 30 minutes after the phenol administration. However, the intestinal lipase activity was obviously inhibited in normal mice and the intestinal lipase activity decline caused by acute lipid consumption can be reversed. It was concluded that the phenols pineapple leave may inhibit the absorption of lipids with correlation to lipase activity. It had certain regulation effect on the high postprandial glucose and fat absorption.