世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2014年
4期
769-773
,共5页
马俊杰%窦英磊%张以来%张静静
馬俊傑%竇英磊%張以來%張靜靜
마준걸%두영뢰%장이래%장정정
活动期溃疡性结肠炎%肺肠同治%灌肠疗法%Th1/Th2
活動期潰瘍性結腸炎%肺腸同治%灌腸療法%Th1/Th2
활동기궤양성결장염%폐장동치%관장요법%Th1/Th2
Active ulcerative colitis%synchronous treatment of lung and intestine%enema method%Th1/Th2
目的：通过肺肠同治方药联合柳氮磺胺吡啶（SASP）灌肠、单独治肠方药联合SASP灌肠及单独SASP灌肠对活动期溃疡性结肠炎（AUC）患者Th1/Th2调节作用的对照研究，证明肺肠同治理论的科学性。方法：将90例中医诊断为热毒炽盛证，西医诊断为AUC的患者随机分为3组，对照组、治肠组和肺肠同治组，每组30例，分别采用单纯SASP灌肠（对照组），白头翁汤、调胃承气汤配合SASP灌肠（治肠组），白头翁汤、凉膈散配合SASP灌肠（肺肠同治组），每日1次，持续60天，各组治疗前后分别进行肠镜检查以进行临床疗效评价，并检测结肠溃疡组织Th1/Th2相关指标。结果：各组临床疗效评价，肺肠同治组>治肠组>对照组，差异具有统计学意义（P<0.05或P<0.01）。与治疗前相比，各组治疗后，Th1（INF-γ、IL-2）皆降低，Th2（IL-4、IL-5）皆升高，Th1/Th2皆降低，差异具有统计学意义（P<0.01）；各组治疗后比较， Th1：对照组>治肠组>肺肠同治组，Th2：肺肠同治组>治肠组>对照组，Th1/Th2：对照组>治肠组>肺肠同治组，差异具有统计学意义（P<0.01）。结论：肺肠同治理论对AUC中药灌肠疗法抗炎具有指导意义。
目的：通過肺腸同治方藥聯閤柳氮磺胺吡啶（SASP）灌腸、單獨治腸方藥聯閤SASP灌腸及單獨SASP灌腸對活動期潰瘍性結腸炎（AUC）患者Th1/Th2調節作用的對照研究，證明肺腸同治理論的科學性。方法：將90例中醫診斷為熱毒熾盛證，西醫診斷為AUC的患者隨機分為3組，對照組、治腸組和肺腸同治組，每組30例，分彆採用單純SASP灌腸（對照組），白頭翁湯、調胃承氣湯配閤SASP灌腸（治腸組），白頭翁湯、涼膈散配閤SASP灌腸（肺腸同治組），每日1次，持續60天，各組治療前後分彆進行腸鏡檢查以進行臨床療效評價，併檢測結腸潰瘍組織Th1/Th2相關指標。結果：各組臨床療效評價，肺腸同治組>治腸組>對照組，差異具有統計學意義（P<0.05或P<0.01）。與治療前相比，各組治療後，Th1（INF-γ、IL-2）皆降低，Th2（IL-4、IL-5）皆升高，Th1/Th2皆降低，差異具有統計學意義（P<0.01）；各組治療後比較， Th1：對照組>治腸組>肺腸同治組，Th2：肺腸同治組>治腸組>對照組，Th1/Th2：對照組>治腸組>肺腸同治組，差異具有統計學意義（P<0.01）。結論：肺腸同治理論對AUC中藥灌腸療法抗炎具有指導意義。
목적：통과폐장동치방약연합류담광알필정（SASP）관장、단독치장방약연합SASP관장급단독SASP관장대활동기궤양성결장염（AUC）환자Th1/Th2조절작용적대조연구，증명폐장동치이론적과학성。방법：장90례중의진단위열독치성증，서의진단위AUC적환자수궤분위3조，대조조、치장조화폐장동치조，매조30례，분별채용단순SASP관장（대조조），백두옹탕、조위승기탕배합SASP관장（치장조），백두옹탕、량격산배합SASP관장（폐장동치조），매일1차，지속60천，각조치료전후분별진행장경검사이진행림상료효평개，병검측결장궤양조직Th1/Th2상관지표。결과：각조림상료효평개，폐장동치조>치장조>대조조，차이구유통계학의의（P<0.05혹P<0.01）。여치료전상비，각조치료후，Th1（INF-γ、IL-2）개강저，Th2（IL-4、IL-5）개승고，Th1/Th2개강저，차이구유통계학의의（P<0.01）；각조치료후비교， Th1：대조조>치장조>폐장동치조，Th2：폐장동치조>치장조>대조조，Th1/Th2：대조조>치장조>폐장동치조，차이구유통계학의의（P<0.01）。결론：폐장동치이론대AUC중약관장요법항염구유지도의의。
This study was aimed to prove the scientific method theory through revealing the effect of synchronous treatment of lung and intestine in the treatment of active ulcerative colitis (AUC) patients. A total of 90 cases with traditional Chinese medicine (TCM) diagnosis of heat-toxin syndrome and western medical diagnosis of AUC were randomly divided into the control group, treatment of intestine group, and synchronous treatment of lung and intestine group, with 30 cases in each group. SASP enema (control group), SASP with Bai-Tou-Weng (BTW) decoction and Tiao-Wei Cheng-Qi (TWCQ) decoction enema (treatment of intestine group), SASP with BTW decoction and Liang-Ge-San (LGS) enema (synchronous treatment of lung and intestine group) were given, respectively. The treatment was given once a day and continued for 60 days. Then, clinical therapeutic evaluation was given before and after the treatment with enteroscopy, Th1/Th2 of ulcerative colon tissues was detected. The results showed that the sequence of clinical effect from top to bottom was synchronous treatment of lung and intestine group, treatment of intestine group, control group, with statistical significance (P< 0.05 or P< 0.01). Comparison of Th1/Th2 before and after treatment among each group showed that Th1 (INF-γ, IL-2) was decreased, Th2 (IL-4, IL-5) was increased (P< 0.05), Th1/Th2 was decreased, with statistical significance (P< 0.01). Comparison among each group after treatment showed that the sequence of Th1 from top to bottom was control group, treatment of intestine group, synchronous treatment of lung and intestine group; that of Th2 was synchronous treatment of lung and intestine group, treatment of intestine group, control group; that of Th1/Th2 was control group, treatment of intestine group, synchronous treatment of lung and in-testine group, with statistical significance (P< 0.01). It was concluded that synchronous treatment of lung and intes-tine had guiding significance on anti-inflammatory effect of enema therapy to AUC.
