CAJ | 학술논문

前列腺癌是老年男性常见的恶性肿瘤。目前，对于前列腺癌晚期患者而言，基因治疗是其最有效的治疗方式。然而，病毒或非病毒载体多存在安全性低、靶向性差、免疫原性高等缺点。超声微泡造影剂作为一种新型基因载体，具有靶向性高、转染率高、安全性高等特点，为晚期前列腺癌患者的基因治疗带来了新的希望。现就该技术在前列腺癌治疗方面的研究进展做一综述。
전렬선암시노년남성상견적악성종류。목전，대우전렬선암만기환자이언，기인치료시기최유효적치료방식。연이，병독혹비병독재체다존재안전성저、파향성차、면역원성고등결점。초성미포조영제작위일충신형기인재체，구유파향성고、전염솔고、안전성고등특점，위만기전렬선암환자적기인치료대래료신적희망。현취해기술재전렬선암치료방면적연구진전주일종술。
Prostate cancer is the most prevalent malignancies in elderly men. At present, gene therapy is the most po-tential treatment for late-stage prostate cancer. However, virus vector or nonvirus vector are less safety, weaker targeting function and higher immunogenic. Ultrasound microcapsular contrast agent as a drug transporter is a new type of disease tar-geted treatment strategies. It has provided a high-targeted, an effective and a safety gene therapy for prostate cancer, and brings a new hope for late-stage prostate cancer patients. This article aims to summarize the recent progress in using the mi-crobubble technology in prostate cancer.