CAJ | 학술논문

目的：探索转化生长因子（TGF）-β1基因多态性与我国人群乙型肝炎肝硬化的关系。方法计算机检索中国生物医学文献数据库、重庆维普中文科技期刊全文数据库、清华CNKI数据库、万方科技期刊全文数据库、Pubmed，检索时间范围为建库到2013年7月。按纳入、排除标准选择TGF-β1基因509位点、869位点基因多态性与乙型肝炎肝硬化关系的病例对照研究。应用RevMan 5.1软件对纳入的研究进行定量分析。结果共纳入6个病例对照研究。Meta分析结果显示509位点携带T等位基因的乙型肝炎肝硬化合并OR值为1.02，95%CI为（0.67~1.54）， CT和TT基因型者乙型肝炎肝硬化合并OR值为0.80，95%CI为（0.36~1.78）；869位点携带C等位基因的乙型肝炎肝硬化的合并OR值为1.05，95%CI为（0.69~1.62），TC和CC基因型者乙型肝炎肝硬化的合并OR值为0.98，95%CI为（0.48~2.00）。未发现显著发表偏倚。结论未发现中国人群中TGF-β1基因多态性与乙型肝炎肝硬化有关系。
목적：탐색전화생장인자（TGF）-β1기인다태성여아국인군을형간염간경화적관계。방법계산궤검색중국생물의학문헌수거고、중경유보중문과기기간전문수거고、청화CNKI수거고、만방과기기간전문수거고、Pubmed，검색시간범위위건고도2013년7월。안납입、배제표준선택TGF-β1기인509위점、869위점기인다태성여을형간염간경화관계적병례대조연구。응용RevMan 5.1연건대납입적연구진행정량분석。결과공납입6개병례대조연구。Meta분석결과현시509위점휴대T등위기인적을형간염간경화합병OR치위1.02，95%CI위（0.67~1.54）， CT화TT기인형자을형간염간경화합병OR치위0.80，95%CI위（0.36~1.78）；869위점휴대C등위기인적을형간염간경화적합병OR치위1.05，95%CI위（0.69~1.62），TC화CC기인형자을형간염간경화적합병OR치위0.98，95%CI위（0.48~2.00）。미발현현저발표편의。결론미발현중국인군중TGF-β1기인다태성여을형간염간경화유관계。
Objective To evaluate the relationship between genetic polymorphism of transforming growth factor (TGF)-β1 and susceptibility of liver cirrhosis after hepatitis B virus infection in Chinese population. Methods CBM, VIP, CNKI, Wanfang technological periodical full-text databases and Pubmed from set up to July, 2013 were electronically searched to identify case-control studies on the relationship between genetic polymorphism of TGF-β1 promoter 509 site, co-don 869 site and liver cirrhosis after hepatitis B virus infection. The data were quantitatively analyzed by RevMan 5.1 soft-ware after assessing the quality of included studies. Results Six case-control studies were selected for Meta-analysis based on our inclusion and exclusion standards. The results of Meta-analysis showed that the pooled OR value for liver cir-rhosis among Chinese patients after hepatitis B virus infection with T allele of TGF-β1 gene at promoter 509 was 1.02 (95%CI:0.67-1.54), the pooled OR values for patients with TT and CT genotypes were 0.80 (95%CI:0.36-1.78). OR values for pa-tients with C allele of TGF-β1 gene at codon 869 was 1.05 (95%CI:0.69-1.62), the pooled OR values for patients with CC and CT genotypes were 0.98 (95%CI:0.48-2.00). No significant publication bias was found. Conclusion The genetic poly-morphism of TGF-β1 at promoter 509 and codon 869 showed no association with susceptibility of liver cirrhosis after hepati-tis B virus infection in Chinese population.