CAJ | 학술논문

目的：建立喂养型胰岛素抵抗（ IR）大鼠模型，观察糖脂平对喂养型IR大鼠糖脂代谢的影响。方法：选用体重在180～200 g的8周龄雄性SD大鼠60只，适应性喂养1周后，随机分为空白对照组15只和造模组45只。空白对照组采用普通饲料喂养，造模组采用高脂饲料喂养。8周造模成功后，将造模组随机分为：模型组、糖脂平组、罗格列酮组各15只。糖脂平组给予糖脂平按生药20 g/（ kg· d）灌胃；罗格列酮组给予罗格列酮0.8 mg/（ kg· d）灌胃；模型组和空白对照组灌服等量的生理盐水；末次给药后禁食12 h，用正常血糖胰岛素钳夹技术来评价胰岛素敏感性，并检测各组大鼠的体重、血糖、血清胰岛素、血脂（ TG、TC、HDL-C、LDL-C）等指标。结果：糖脂平能够增加胰岛素敏感性，改善胰岛素抵抗，抑制体重增长，效果优于罗格列酮；同时可降低血糖、空腹血清胰岛素，降低TG和LDL-c，与罗格列酮药效相近。结论：糖脂平能够调整IR大鼠的糖脂代谢紊乱，改善胰岛素抵抗。
목적：건립위양형이도소저항（ IR）대서모형，관찰당지평대위양형IR대서당지대사적영향。방법：선용체중재180～200 g적8주령웅성SD대서60지，괄응성위양1주후，수궤분위공백대조조15지화조모조45지。공백대조조채용보통사료위양，조모조채용고지사료위양。8주조모성공후，장조모조수궤분위：모형조、당지평조、라격렬동조각15지。당지평조급여당지평안생약20 g/（ kg· d）관위；라격렬동조급여라격렬동0.8 mg/（ kg· d）관위；모형조화공백대조조관복등량적생리염수；말차급약후금식12 h，용정상혈당이도소겸협기술래평개이도소민감성，병검측각조대서적체중、혈당、혈청이도소、혈지（ TG、TC、HDL-C、LDL-C）등지표。결과：당지평능구증가이도소민감성，개선이도소저항，억제체중증장，효과우우라격렬동；동시가강저혈당、공복혈청이도소，강저TG화LDL-c，여라격렬동약효상근。결론：당지평능구조정IR대서적당지대사문란，개선이도소저항。
Objective:To investigate the effects of Tangzhiping on glucose and lipid metabolism in rats with insulin resistance .Meth-ods:Sixty male SD rats which were 8 weeks old and weighted among 180 to 200 g were randomly divided into blank control group ( n=15) and module group (n=45) after being fed for a week for adaptation .Rats in the blank control group were fed with common food , while module group fed the rats with high fat food for 8 weeks.Eight weeks later, the model rats were successfully made , and they were randomly divided into:the model group (n=15), Tangzhiping group (n=15), rosiglitazone group (n=15).Tangzhiping group gave the rats Tangzhiping formula particles according to the statement 20 g/kg/d to fill in the stomach;rosiglitazone group applied up to 0.8 mg/kg/d rosiglitazone gavage;model group and blank control group used the same amount of saline solution for 8weeks.Twelve hours after the last administration , levels of insulin sensitivity was evaluated by the “euglycemic hyperinsulin clamp technique”, and levels of body weight, fast plasma glucose, serum insulin, blood lipids were also observed .Results:Tangzhiping could raise insulin sensitivity , improve IR, suppress weight gain which was better than rosiglitazone;it could lower blood sugar, reduce serum insulin, TG and LDL-c, which was close to the efficacy of rosiglitazone .Conclusion: IR model is successfully established .Tangzhiping and rosiglitazone can lose weight , reduce blood sugar and insulin levels , adjust blood lipid levels and increase insulin sensitivity .