CAJ | 학술논문

目的：探讨高敏C-反应蛋白（hs-CRP）联合免疫功能检测在儿童肺炎支原体肺炎（MPP）中的临床意义。方法选取单纯MPP患儿103例，分为全身炎症反应综合征（SIRS）组47例和非SIRS组56例，另取26例健康儿童作为对照组，检测hs-CRP、体液免疫指标及细胞免疫指标。结果 SIRS组和非SIRS组的血清hs-CRP、IgG、IgM、CD8+水平显著高于对照组，而IgA、CD3+、CD4+、CD4+/CD8+水平显著低于对照组，差异均有统计学意义（P均<0.05）；SIRS组的hs-CRP、IgG显著高于非SIRS组，而IgA、CD3+、CD4+、CD4+/CD8+水平则显著低于非SIRS组，差异均有统计学意义（P均<0.05）；SIRS组和非SIRS组的IgM与CD8+水平的差异则无统计学意义（P>0.05）。结论 MPP患儿的体液免疫及细胞免疫功能均有紊乱，且与病情有关；hs-CRP有助于判断儿童MPP病情程度。
목적：탐토고민C-반응단백（hs-CRP）연합면역공능검측재인동폐염지원체폐염（MPP）중적림상의의。방법선취단순MPP환인103례，분위전신염증반응종합정（SIRS）조47례화비SIRS조56례，령취26례건강인동작위대조조，검측hs-CRP、체액면역지표급세포면역지표。결과 SIRS조화비SIRS조적혈청hs-CRP、IgG、IgM、CD8+수평현저고우대조조，이IgA、CD3+、CD4+、CD4+/CD8+수평현저저우대조조，차이균유통계학의의（P균<0.05）；SIRS조적hs-CRP、IgG현저고우비SIRS조，이IgA、CD3+、CD4+、CD4+/CD8+수평칙현저저우비SIRS조，차이균유통계학의의（P균<0.05）；SIRS조화비SIRS조적IgM여CD8+수평적차이칙무통계학의의（P>0.05）。결론 MPP환인적체액면역급세포면역공능균유문란，차여병정유관；hs-CRP유조우판단인동MPP병정정도。
Objectives To detect the clinical significance of high sensitive C-reactive protein (hs-CRP) and immune function in children with Mycoplasma pneumoniae pneumonia (MPP). Methods 103 children with MPP, 47 cases of systemic inflammatory response syndrome (SIRS group), 56 cases of non-systemic inflammatory response syndrome (non-SIRS group) were recruited. 26 healthy children served as the control group. ELISA was used to detect the level of serum hs-CRP, immune in-dexes, IgG, IgA, and IgM, Cellular immune CD3+, CD4+, CD8+, CD4+/CD8+. Results The level of serum hs-CRP、IgG、IgM and CD8+in control group were significantly lower than those in non-SIRS group and SIRS group (P<0.05). The level of IgA、CD3+, CD4+, CD4+/CD8+in control group were significantly higher than those in non-SIRS group and SIRS group (P<0.05). The level of serum hs-CRP、IgG in SIRS group were significantly higher than those in non-SIRS group (P<0.05). The level of IgA、CD3+、CD4+、CD4+/CD8+in SIRS group were significantly lower than those in non-SIRS group. There was no significant difference in non-SIRS group and SIRS group of IgM and CD8+(P>0.05). The level change of serum hs-CRP were positively related with IgG (r=0.66,P=0.001) and were negatively related with IgA、CD4+、CD4+/CD8+(r=0.79, 0.67, 0.82, P all were<0.05) in chil-dren with MPP. Conclusion Children with MPP have Immunity function( including humoral immunity and cellular immunity) disorder which is related to the disease status. The level of hs-CRP could be an anpation index for the severity and immune func-tion of the children with MPP.