临床儿科杂志
臨床兒科雜誌
림상인과잡지
2014年
5期
453-455
,共3页
李佳凤%王世彪%刘光华%阮冠宇%曾凡湘
李佳鳳%王世彪%劉光華%阮冠宇%曾凡湘
리가봉%왕세표%류광화%원관우%증범상
β-内酰胺类%大环内酯类%联合用药%社区获得性肺炎
β-內酰胺類%大環內酯類%聯閤用藥%社區穫得性肺炎
β-내선알류%대배내지류%연합용약%사구획득성폐염
β-lactam antibiotics%macrolides%combination therapy%community-acquired pneumonia
目的：探讨β-内酰胺类联合大环内酯类抗菌药物治疗重症儿童社区获得性肺炎（CAP）的临床疗效。方法回顾性分析2012年2月至2012年4月期间住院重症CAP患儿在相同对症支持治疗基础上，采用头孢美唑联合阿奇霉素（研究组）或单用头孢美唑（对照组），在总有效率、体温下降、咳嗽减轻和啰音消失时间以及住院天数方面的差异。结果研究组的总有效率为87.76%，高于对照组（61.22%），两组间差异有统计学意义（χ2=9.08，P=0.003）。研究组体温恢复正常时间、咳嗽消失时间、肺部啰音消失时间以及住院天数分别为（1.82±1.17）d（、6.86±2.06）d（、6.30±2.04）d和（7.28±2.11）d，均短于对照组的（3.25±4.35）d、（9.72±3.96）d、（8.79±4.00）d和（10.14±3.94）d，差异均有统计学意义（Z=3.52~5.53，P均<0.05）。结论阿奇霉素联合头孢美唑治疗CAP疗效确切，重症CAP患儿联合应用β-内酰胺类与大环内酯类抗菌药物合理且有效。
目的：探討β-內酰胺類聯閤大環內酯類抗菌藥物治療重癥兒童社區穫得性肺炎（CAP）的臨床療效。方法迴顧性分析2012年2月至2012年4月期間住院重癥CAP患兒在相同對癥支持治療基礎上，採用頭孢美唑聯閤阿奇黴素（研究組）或單用頭孢美唑（對照組），在總有效率、體溫下降、咳嗽減輕和啰音消失時間以及住院天數方麵的差異。結果研究組的總有效率為87.76%，高于對照組（61.22%），兩組間差異有統計學意義（χ2=9.08，P=0.003）。研究組體溫恢複正常時間、咳嗽消失時間、肺部啰音消失時間以及住院天數分彆為（1.82±1.17）d（、6.86±2.06）d（、6.30±2.04）d和（7.28±2.11）d，均短于對照組的（3.25±4.35）d、（9.72±3.96）d、（8.79±4.00）d和（10.14±3.94）d，差異均有統計學意義（Z=3.52~5.53，P均<0.05）。結論阿奇黴素聯閤頭孢美唑治療CAP療效確切，重癥CAP患兒聯閤應用β-內酰胺類與大環內酯類抗菌藥物閤理且有效。
목적：탐토β-내선알류연합대배내지류항균약물치료중증인동사구획득성폐염（CAP）적림상료효。방법회고성분석2012년2월지2012년4월기간주원중증CAP환인재상동대증지지치료기출상，채용두포미서연합아기매소（연구조）혹단용두포미서（대조조），재총유효솔、체온하강、해수감경화라음소실시간이급주원천수방면적차이。결과연구조적총유효솔위87.76%，고우대조조（61.22%），량조간차이유통계학의의（χ2=9.08，P=0.003）。연구조체온회복정상시간、해수소실시간、폐부라음소실시간이급주원천수분별위（1.82±1.17）d（、6.86±2.06）d（、6.30±2.04）d화（7.28±2.11）d，균단우대조조적（3.25±4.35）d、（9.72±3.96）d、（8.79±4.00）d화（10.14±3.94）d，차이균유통계학의의（Z=3.52~5.53，P균<0.05）。결론아기매소연합두포미서치료CAP료효학절，중증CAP환인연합응용β-내선알류여대배내지류항균약물합리차유효。
Objective To investigate the clinical efficacy ofβ-lactam combined with macrolides antibiotics in treatment of severe community-acquired pneumonia (CAP) in children. Methods Children with severe CAP on admission between 2012 February and 2012 April were divided into treatment group and control group. With the same symptom specific supportive treat-ment, the patients in the treatment group were treated with both cefmetazole and azithromycin, while the patients in the control group were treated with cefmetazole alone. The total effective rate, number of days of symptoms and signs disappeared and num-ber of days of hospitalization were observed. Results The total effective rate was 87.8%in the trearment group and 61.3%in the control group with significant difference (P<0.05). Compared with control group, the recovery time of temperature, time of pulmonary rale disappearing and cough retraction were reduced (P<0.05). As well as the number of days of hospitalization was decreased (P<0.05). Conclusions The treatment of severe CAP in children with combination of azithromycin and cefmetazole results in better curative effect. A combined medication ofβ-lactam and macrolides antibiotics may be rational and effective.
