CAJ | 학술논문

目的：总结儿童肝母细胞瘤（HB）的治疗效果，探讨合理治疗策略。方法回顾性分析2009年2月至2013年3月初治的HB患儿的临床及随访资料。结果入选25例初治HB患儿，男14例、女11例，中位发病年龄为25个月（3~92个月）。其中原发肿瘤完整切除18例，存活17例；未完全切除7例，仅1例存活；原发肿瘤完整切除者的生存率明显高于未完整切除者，Ⅰ、Ⅱ期患儿生存率明显高于Ⅲ、Ⅳ期患儿，差异均有统计学意义（P均<0.05）。结论手术完整切除是所有临床分期的HB患儿获得长期无瘤生存的关键，对于复发和转移的HB患儿的治疗策略有待进一步完善。
목적：총결인동간모세포류（HB）적치료효과，탐토합리치료책략。방법회고성분석2009년2월지2013년3월초치적HB환인적림상급수방자료。결과입선25례초치HB환인，남14례、녀11례，중위발병년령위25개월（3~92개월）。기중원발종류완정절제18례，존활17례；미완전절제7례，부1례존활；원발종류완정절제자적생존솔명현고우미완정절제자，Ⅰ、Ⅱ기환인생존솔명현고우Ⅲ、Ⅳ기환인，차이균유통계학의의（P균<0.05）。결론수술완정절제시소유림상분기적HB환인획득장기무류생존적관건，대우복발화전이적HB환인적치료책략유대진일보완선。
Objectives To investigate the rational treatment strategy of hepatoblastoma (HB) in children. Methods Clinical data and follow-up of 25 children with HB admitted from February 2009 to March 2013 were retrospectively analyzed. Results Twenty-five children with newly diagnosed HB (14 males and 11 females) were enrolled. The median age on diagnosis was 25 months (3-92 months);In 18 of 25 cases with complete resection of the primary tumor, 17 cases survived. Only 1 of 7 cases with incomplete resection survived. The survival rate in children with complete resection of primary tumor is significantly higher than those without complete resection (P<0.05). The survival rate in children of stage I or II is significantly higher than the children of stage III or IV (P<0.05). Conclusions Complete tumor resection is the cornerstone of therapy for long-term disease-free survival in HB patients. Treatment strategy remains to be further improved for children with recurrent and metastatic HB.