检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2014年
5期
483-487
,共5页
丙氨酸氨基转移酶%天门冬氨酸氨基转移酶%乙型肝炎病毒脱氧核糖核酸%诊断界值%慢性乙型肝炎
丙氨痠氨基轉移酶%天門鼕氨痠氨基轉移酶%乙型肝炎病毒脫氧覈糖覈痠%診斷界值%慢性乙型肝炎
병안산안기전이매%천문동안산안기전이매%을형간염병독탈양핵당핵산%진단계치%만성을형간염
Alanine aminotransferase%Aspartate aminotransferase%Hepatitis B virus deoxyribonucleic acid%Cut-off value%Chronic hepatitis B
目的：建立和评估丙氨酸氨基转移酶（ALT）、乙型肝炎病毒（HBV）DNA和天门冬氨酸氨基转移酶（AST）对乙型肝炎e抗原（HBeAg）阴性活动性乙型肝炎的诊断界值（Cut-off值）。方法将290例HBeAg阴性的慢性乙型肝炎患者以肝组织活检结果为标准分为活动性（213例）和非活动性（77例）慢性乙型肝炎，用受试者工作特征（ROC）曲线评价ALT、AST和 HBV DNA 载量在诊断HBeAg阴性的活动性慢性乙型肝炎中的价值。结果血清中ALT、AST、HBV DNA载量的ROC曲线下面积（AUC）分别为0．849、0．807、0．867；诊断界值为男性ALT 30 IU/L、女性ALT 19 IU/L，HBV DNA载量1×105拷贝/mL时的敏感性为90．6％、特异性为98．7％、阳性预测值为99．5％、阴性预测值为79．2％；AST以40 IU/L作为Cut-off值时的敏感性为77．0％、特异性为63．3％、阳性预测值为85．4％、阴性预测值为50．0％。结论可以以男性ALT 30 IU/L、女性ALT 19 IU/L且HBV DNA载量1×105拷贝/mL作为中国四川自贡地区HBeAg阴性的慢性活动性乙型肝炎的诊断Cut-off值。
目的：建立和評估丙氨痠氨基轉移酶（ALT）、乙型肝炎病毒（HBV）DNA和天門鼕氨痠氨基轉移酶（AST）對乙型肝炎e抗原（HBeAg）陰性活動性乙型肝炎的診斷界值（Cut-off值）。方法將290例HBeAg陰性的慢性乙型肝炎患者以肝組織活檢結果為標準分為活動性（213例）和非活動性（77例）慢性乙型肝炎，用受試者工作特徵（ROC）麯線評價ALT、AST和 HBV DNA 載量在診斷HBeAg陰性的活動性慢性乙型肝炎中的價值。結果血清中ALT、AST、HBV DNA載量的ROC麯線下麵積（AUC）分彆為0．849、0．807、0．867；診斷界值為男性ALT 30 IU/L、女性ALT 19 IU/L，HBV DNA載量1×105拷貝/mL時的敏感性為90．6％、特異性為98．7％、暘性預測值為99．5％、陰性預測值為79．2％；AST以40 IU/L作為Cut-off值時的敏感性為77．0％、特異性為63．3％、暘性預測值為85．4％、陰性預測值為50．0％。結論可以以男性ALT 30 IU/L、女性ALT 19 IU/L且HBV DNA載量1×105拷貝/mL作為中國四川自貢地區HBeAg陰性的慢性活動性乙型肝炎的診斷Cut-off值。
목적：건립화평고병안산안기전이매（ALT）、을형간염병독（HBV）DNA화천문동안산안기전이매（AST）대을형간염e항원（HBeAg）음성활동성을형간염적진단계치（Cut-off치）。방법장290례HBeAg음성적만성을형간염환자이간조직활검결과위표준분위활동성（213례）화비활동성（77례）만성을형간염，용수시자공작특정（ROC）곡선평개ALT、AST화 HBV DNA 재량재진단HBeAg음성적활동성만성을형간염중적개치。결과혈청중ALT、AST、HBV DNA재량적ROC곡선하면적（AUC）분별위0．849、0．807、0．867；진단계치위남성ALT 30 IU/L、녀성ALT 19 IU/L，HBV DNA재량1×105고패/mL시적민감성위90．6％、특이성위98．7％、양성예측치위99．5％、음성예측치위79．2％；AST이40 IU/L작위Cut-off치시적민감성위77．0％、특이성위63．3％、양성예측치위85．4％、음성예측치위50．0％。결론가이이남성ALT 30 IU/L、녀성ALT 19 IU/L차HBV DNA재량1×105고패/mL작위중국사천자공지구HBeAg음성적만성활동성을형간염적진단Cut-off치。
Objective To establish and assess the cut-off value for alanine aminotransferase (ALT),hepatitis B virus (HBV)DNA and aspartate aminotransferase(AST)to diagnose hepatitis B eantigen (HBeAg)negative chronic active hepatitis B.Methods A total of 290 HBeAg negative chronic hepatitis B patients were enrolled and classified into 2 groups:active (213 cases)and inactive(77 cases)groups according to liver biopsy.The diagnosis significance for ALT,AST and HBV DNA load in HBeAg negative chronic active hepatitis B was evaluated by receiver operating characteristic (ROC)curves.Results The areas under ROC curve (AUC)for serum ALT,AST and HBV DNA load were 0.849,0.807 and 0.867,respectively.For the cut-off values of 30 IU/L for male ALT and 19 IU/L for female ALT and HBV DNA load 1 ×105 copies/mL,the sensitivity was 90.6%,the specificity was 98.7%,the positive predictive value was 99.5%,and the negative predictive value was 79.2%.The sensitivity of 77.0%,specificity of 63.3%,positive predictive value of 85.4% and negative predictive value of 50.0% were also observed for AST 40 IU/L as the cut-off value.Conclusions The 30 IU/L for male ALT and 19 IU/L for female ALT and HBV DNA load 1 ×105 copies/mL are suggested to be the cut-off values for discriminating HBeAg negative chronic active hepatitis B.
