检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2014年
5期
464-467
,共4页
熊遹%钱士匀%熊小泉%崔开媚%蔡群芳%邬强
熊遹%錢士勻%熊小泉%崔開媚%蔡群芳%鄔彊
웅휼%전사균%웅소천%최개미%채군방%오강
25 羟基-维生素D%成人%参考区间
25 羥基-維生素D%成人%參攷區間
25 간기-유생소D%성인%삼고구간
25-hydroxy vitamin D%Adult%Reference interval
目的：对海南地区健康成人25羟基-维生素D（25 OH-D）参考区间进行调查，为合理补充维生素D提供科学依据。方法选择海南地区生活背景相似、年龄不同的健康体检者1978名（男1008名、女970名），收集对象的基本资料，采用电化学发光法测定所有对象的血清25 OH-D水平。按性别和年龄分别分组进行统计分析。结果调查所用的25 OH-D检测系统准确度、精密度良好。血清25 OH-D水平呈非正态分布，采用百分位数（P2．5～P97．5）设立参考区间。男、女性间血清25OH-D水平差异有统计学意义（P＜0．01）；≤50岁及＞50岁男、女性之间血清25OH-D水平差异均有统计学意义（P均＜0．01）；男性≤50岁的参考区间为6．77～26．80 ng/mL，＞50岁的参考区间为4．51～19．73 ng/mL；女性≤50岁的参考区间为5．96～24．79 ng/mL，＞50岁的参考区间为3．71～16．34 ng/mL。结论针对海南地区人群的实际情况，建立了不同性别和年龄的25OH-D参考区间。
目的：對海南地區健康成人25羥基-維生素D（25 OH-D）參攷區間進行調查，為閤理補充維生素D提供科學依據。方法選擇海南地區生活揹景相似、年齡不同的健康體檢者1978名（男1008名、女970名），收集對象的基本資料，採用電化學髮光法測定所有對象的血清25 OH-D水平。按性彆和年齡分彆分組進行統計分析。結果調查所用的25 OH-D檢測繫統準確度、精密度良好。血清25 OH-D水平呈非正態分佈，採用百分位數（P2．5～P97．5）設立參攷區間。男、女性間血清25OH-D水平差異有統計學意義（P＜0．01）；≤50歲及＞50歲男、女性之間血清25OH-D水平差異均有統計學意義（P均＜0．01）；男性≤50歲的參攷區間為6．77～26．80 ng/mL，＞50歲的參攷區間為4．51～19．73 ng/mL；女性≤50歲的參攷區間為5．96～24．79 ng/mL，＞50歲的參攷區間為3．71～16．34 ng/mL。結論針對海南地區人群的實際情況，建立瞭不同性彆和年齡的25OH-D參攷區間。
목적：대해남지구건강성인25간기-유생소D（25 OH-D）삼고구간진행조사，위합리보충유생소D제공과학의거。방법선택해남지구생활배경상사、년령불동적건강체검자1978명（남1008명、녀970명），수집대상적기본자료，채용전화학발광법측정소유대상적혈청25 OH-D수평。안성별화년령분별분조진행통계분석。결과조사소용적25 OH-D검측계통준학도、정밀도량호。혈청25 OH-D수평정비정태분포，채용백분위수（P2．5～P97．5）설립삼고구간。남、녀성간혈청25OH-D수평차이유통계학의의（P＜0．01）；≤50세급＞50세남、녀성지간혈청25OH-D수평차이균유통계학의의（P균＜0．01）；남성≤50세적삼고구간위6．77～26．80 ng/mL，＞50세적삼고구간위4．51～19．73 ng/mL；녀성≤50세적삼고구간위5．96～24．79 ng/mL，＞50세적삼고구간위3．71～16．34 ng/mL。결론침대해남지구인군적실제정황，건립료불동성별화년령적25OH-D삼고구간。
Objective To survey the reference intervals of serum 25-hydroxy vitamin D(25OH-D)from adults in Hainan area,and provide scientific reference for reasonable supplement of vitamin D.Methods Basic data of 1 978 healthy subjects(1 008 males and 970 females)with similar livelihood background and different ages were collected, and the level of serum 25 OH-D was analyzed by electro-chemiluminescence.The subjects were classified according to sex and age,and the results were analyzed statistically.Results The accuracy and precision of the 25 OH-D detection system were good,and the levels of serum 25OH-D had non-Gaussian distribution.The reference intervals were established by percentile (P2.5-P97.5 ).There were statistical significances of 25 OH-D between males and females (P<0.01).There was statistical significance between ≤50 years old and >50 years old among males and females(P<0.01).The reference interval of males ≤50 years old was 6.77-26.80 ng/mL,and that of males >50 years old was 4.51-19.73 ng/mL.The reference interval of females ≤50 years old was 5.96-24.79 ng/mL and that of females >50 years old was 3.71-16.34 ng/mL.Conclusions The reference interval for specific sex and age should be established for the population of Hainan area.
