CAJ | 학술논문

目的：观察清眩颗粒干预代谢综合征及其对脂肪因子影响。方法将98例代谢综合征患者随机分为2组。治疗组50例在行为干预的基础上口服清眩颗粒，对照组48例口服二甲双胍。2组均2个月为1个疗程，3个疗程统计临床疗效，并观察2组治疗前后血压、体质量指数、血糖、血脂及脂肪因子情况。结果治疗组收缩压、舒张压治疗后均降低（P＜0．01，P＜0．05），对照组收缩压治疗后降低（P＜0．05），且治疗组降低收缩压优于对照组（P＜0．01）。治疗组控制收缩压的疗效优于对照组（P＜0．01）。2组治疗后体质量、体质量指数、空腹血糖、胰岛素抵抗（IR）指数及空腹胰岛素均改善（P＜0．05），组间比较差异无统计学意义（P＞0．05）。2组治疗后胆固醇、低密度脂蛋白胆固醇均改善（P＜0．05），组间比较差异无统计学意义（P＞0．05）；治疗组治疗后升高高密度脂蛋白胆固醇、降低甘油三酯优于对照组治疗后（P＜0．05）。治疗组治疗后脂肪因子（视黄醇结合蛋白-4、脂肪素、脂联素、抵抗素、纤溶酶原激活物抑制因子）均改善（P＜0．05）。结论清眩颗粒具有干预代谢综合征、调节脂肪因子的疗效。
목적：관찰청현과립간예대사종합정급기대지방인자영향。방법장98례대사종합정환자수궤분위2조。치료조50례재행위간예적기출상구복청현과립，대조조48례구복이갑쌍고。2조균2개월위1개료정，3개료정통계림상료효，병관찰2조치료전후혈압、체질량지수、혈당、혈지급지방인자정황。결과치료조수축압、서장압치료후균강저（P＜0．01，P＜0．05），대조조수축압치료후강저（P＜0．05），차치료조강저수축압우우대조조（P＜0．01）。치료조공제수축압적료효우우대조조（P＜0．01）。2조치료후체질량、체질량지수、공복혈당、이도소저항（IR）지수급공복이도소균개선（P＜0．05），조간비교차이무통계학의의（P＞0．05）。2조치료후담고순、저밀도지단백담고순균개선（P＜0．05），조간비교차이무통계학의의（P＞0．05）；치료조치료후승고고밀도지단백담고순、강저감유삼지우우대조조치료후（P＜0．05）。치료조치료후지방인자（시황순결합단백-4、지방소、지련소、저항소、섬용매원격활물억제인자）균개선（P＜0．05）。결론청현과립구유간예대사종합정、조절지방인자적료효。
Objective To observe the effect of Qingxuan granule on metabolic syndrome and adipocyte fac-tor.Methods 98 patients with metabolic syndrome were randomly divided into two groups .50 cases in treatment group orally received Qingxuan granule on the basis of behavioral interventions .48 cases of the control group received oral metformin.The therapeutic course was two months in two groups .The clinical effect was observed after three cour-ses.The status of blood pressure,blood glucose,blood lipid,BMI and adipocyte factors were recorded before and after treatment .Results Systolic blood pressure and diastolic blood pressure after treatment were lower in treatment group (P<0.01,P<0.05) and systolic blood pressure after treatment was reduced in control group (P<0.05).The de-crease of systolic blood pressure in treatment group was superior to that in control group (P<0.01).Body mass,body mass index (BMI),fasting glucose,IR,fasting insulin,TC and LDL-C after treatment are improved in two groups (P<0.05).But there was no significant difference between two groups (P>0.05).The increase of HDL-C and the decrease of TG in treatment group was superior to that in control group after treatment (P<0.05).Adipocyte factors (Retinol binding protein 4,adipokine,adiponectin,resistin,fibrinolytic enzyme activation inhibiting factor ) were im-proved after treatment in treatment group (P<0.05).Conclusion Qingxuan particles have the efficacy of interven-tions on metabolic syndrome and can regulate adipokines .