CAJ | 학술논문

目的：探讨联合测定不同病因胸腔积液中分泌型白细胞蛋白酶抑制因子（SLPI）、干扰素-γ（IFN-γ）和腺苷脱氨酶（ADA）的浓度对结核性胸腔积液的诊断价值。方法：收集93例胸腔积液及其同源外周血，分为结核组、恶性组、细菌感染组及漏出液组。测定三种指标浓度，并对结果及意义进行分析。结果：结核组胸水SLPI、IFN-γ及ADA浓度较恶性组、感染组及漏出液组比较有统计学差异（P＜0．05）。受试者工作特征曲线（ROC曲线）结果显示SLPI、IFN-γ和ADA对于诊断结核性胸腔积液均具有较高诊断效能；联合SLPI、IFN-γ和ADA能提高结核性胸腔积液诊断效能，其中以三者联合诊断效能最佳。结论：单独测定SLPI、IFN-γ及ADA均有助于诊断结核性胸腔积液，但联合测定更能提高诊断效能。
목적：탐토연합측정불동병인흉강적액중분비형백세포단백매억제인자（SLPI）、간우소-γ（IFN-γ）화선감탈안매（ADA）적농도대결핵성흉강적액적진단개치。방법：수집93례흉강적액급기동원외주혈，분위결핵조、악성조、세균감염조급루출액조。측정삼충지표농도，병대결과급의의진행분석。결과：결핵조흉수SLPI、IFN-γ급ADA농도교악성조、감염조급루출액조비교유통계학차이（P＜0．05）。수시자공작특정곡선（ROC곡선）결과현시SLPI、IFN-γ화ADA대우진단결핵성흉강적액균구유교고진단효능；연합SLPI、IFN-γ화ADA능제고결핵성흉강적액진단효능，기중이삼자연합진단효능최가。결론：단독측정SLPI、IFN-γ급ADA균유조우진단결핵성흉강적액，단연합측정경능제고진단효능。
Objective To compare the diagnostic significance of pleural SLPI,IFN-γ and ADA for differenti-ating TPE from pleural effusions with the other etiologies. Methods Pleural effusion samples were obtained from 93 patients who were divided into the following groups: tuberculous pleural effusion,malignant pleural effusion, bacterial pleural effusion and transudative pleural effusion. The pleural effusion and/or serum levels of SLPI , IFN-γand ADA were determined. Results 1.The concentrations of SLPI, IFN-γand ADA in tuberculous pleural effusion was higher than that in malignant group, bacterial group and transudative group. 2. The diagnostic value of SLPI, IFN-γor ADA for the diagnosis of tuberculous PE is high respectively. The combinations of SLPI, IFN-γand/or ADA gained the more valuable diagnostic performance. Conclusion Pleural SLPI, IFN-γand ADA may be helpful for the differential diagnosis of tuberculous pleural effusion and the other pleural effusion. The combinations of SLPI or/and IFN-γor/and ADA further increased diagnostic value.