CAJ | 학술논문

目的：探讨超声造影在评价下肢动脉硬化闭塞症（ Lower extremity arterial disease ，LEAD ）的骨骼肌灌注障碍的应用价值。方法收集80例正常对照组和80例LEAD患者，用超声造影观察小腿骨骼肌运动前后血流灌注情况，运用数学模型分析时间-强度曲线，得出灌注参数达峰时间（ time to peak intensity ，TTP）。结果时间-强度曲线显示在静息时对照组TTP 38 s（19～65 s），LEAD组TTP 84 s（39～142 s），2组比较差异有统计学意义（ P ＜0 f．01），小腿运动试验后，正常对照组TTP 11 s（9～22 s），LEAD组TTP 52 s（27～105 s），2组比较差异有统计学意义（ P ＜0．01），年龄校正后，2组比较差异有统计学意义（ P ＜0．01）。 TTP和踝肱指数、年龄均无明显相关性（ P ＞0．05）。结论超声造影是一种评价骨骼肌灌注障碍的新型的诊断方法。
목적：탐토초성조영재평개하지동맥경화폐새증（ Lower extremity arterial disease ，LEAD ）적골격기관주장애적응용개치。방법수집80례정상대조조화80례LEAD환자，용초성조영관찰소퇴골격기운동전후혈류관주정황，운용수학모형분석시간-강도곡선，득출관주삼수체봉시간（ time to peak intensity ，TTP）。결과시간-강도곡선현시재정식시대조조TTP 38 s（19～65 s），LEAD조TTP 84 s（39～142 s），2조비교차이유통계학의의（ P ＜0 f．01），소퇴운동시험후，정상대조조TTP 11 s（9～22 s），LEAD조TTP 52 s（27～105 s），2조비교차이유통계학의의（ P ＜0．01），년령교정후，2조비교차이유통계학의의（ P ＜0．01）。 TTP화과굉지수、년령균무명현상관성（ P ＞0．05）。결론초성조영시일충평개골격기관주장애적신형적진단방법。
Objective To explore the application value of contrast-enhanced ultrasound ( CEUS ) in the diagnosis of lower extremity arterial disease ( LEAD) .Met hods Ultrasound contrast agent was injected into peripheral vein of 80 healthy subjects and 80 patients with LEAD .The condition of blood flow perfusion in calf muscle was detected by contrast-enhanced ultrasound.Time intensity curve (TIC) was analyzed by mathematical model to get the time to peak intensity (TTP).Results TIC revealed TTP in patients with LEAD was 84s(39~142s)at rest period,which was 38s(19~65s in control group,there was a significant difference between LEAD group and control group ( P <0.01).After leg exercise test,TTP in control group was 11s(9~22s),however,which was 52s(27 ~105s) in LEAD group,there was a significant difference between LEAD group and control group ( P <0.01).After age adjustment there was a significant difference between LEAD group and control group ( P <0.01).However TTP was not correlated to patient's age and ankle brachium index .Conclusion CEUS is an novel diagnostic method for evaluating perfusion disorder of skeletal muscles .