CAJ | 학술논문

目的：评价局部注射卡介菌多糖核酸治疗口腔扁平苔藓的短期疗效。方法将60例口腔黏膜扁平苔藓患者随机分为治疗组和对照组各30例，治疗组局部注射卡介菌多糖核酸治疗，对照组则采用曲安奈德局部注射治疗，同时记录两组患者的视觉类比量表(VAS)和REU scoring system (REU)分值，并在治疗后2周和4周时对其有效率进行评定。结果治疗组第2周、第4周的VAS、REU分值较对照组有明显降低，差异具有统计学意义(P<0.05)；治疗组第2周、第4周治疗的有效率与对照组比较，差异均具有统计学意义(P<0.05)。结论卡介菌多糖核酸局部注射治疗口腔扁平苔藓不失为一种安全有效的短效治疗方法，值得临床推广应用。
목적：평개국부주사잡개균다당핵산치료구강편평태선적단기료효。방법장60례구강점막편평태선환자수궤분위치료조화대조조각30례，치료조국부주사잡개균다당핵산치료，대조조칙채용곡안내덕국부주사치료，동시기록량조환자적시각류비량표(VAS)화REU scoring system (REU)분치，병재치료후2주화4주시대기유효솔진행평정。결과치료조제2주、제4주적VAS、REU분치교대조조유명현강저，차이구유통계학의의(P<0.05)；치료조제2주、제4주치료적유효솔여대조조비교，차이균구유통계학의의(P<0.05)。결론잡개균다당핵산국부주사치료구강편평태선불실위일충안전유효적단효치료방법，치득림상추엄응용。
Objective To evaluate the efficacy and safety of topical intralesional injection of BCG-PSN in the treatment of oral lichen planus. Methods 60 patients with clinically confirmed erosive and ulcerative OLP were randomly divided into two groups, treated with BCG-PSN and TA separately, meanwhile the VAS and REU scoring system was utilized to compare the signs and symptoms. Results The VAS, REU scores decreased signifficantly,in the treatment group on the second and the fourth week compared with them in the control group (P<0.05);the efficien-cy rate were significantly improved in the treatment group on the second and the fourth week compared with them in the control group (P<0.05). Conclusion Topical intralesional injection of BCG-PSN was an effective and safe meth-od in the treatment of OLP, which is worthy of clinical application.