CAJ | 학술논문

目的：观察EV-71感染对手足口病患儿血清神经元特异性烯醇化酶(NSE)水平的影响，探讨其感染与神经系统损伤的相关性，为潜在神经系统损伤的早期干预及治疗提供理论依据。方法随机收集2011年4月至2012年11月间在本院儿内科治疗的100例手足口病患儿的临床资料，依据血清EV-71抗体检测结果分为阳性组43例和阴性组57例；同时选择在本院保健科进行体检的健康儿童80例作为对照组。应用电化学发光法进行血清NSE含量测定。对手足口病组和对照组、EV-71阳性组和阴性组血清NSE值进行对比分析。结果手足口病组和对照组比较，血清NSE水平偏高，差异有显著统计学意义(P<0.01)；EV-71阳性组和阴性组患儿比较，血清NSE水平明显高于阴性组，差异有显著统计学意义(P<0.01)。结论手足口病患儿血清NSE水平较正常儿童有明显偏高， EV-71阳性患儿最为明显，提示手足口病患儿较正常儿童易并发神经系统损伤，EV-71感染的手足口病患儿神经系统损伤相对更为严重。
목적：관찰EV-71감염대수족구병환인혈청신경원특이성희순화매(NSE)수평적영향，탐토기감염여신경계통손상적상관성，위잠재신경계통손상적조기간예급치료제공이론의거。방법수궤수집2011년4월지2012년11월간재본원인내과치료적100례수족구병환인적림상자료，의거혈청EV-71항체검측결과분위양성조43례화음성조57례；동시선택재본원보건과진행체검적건강인동80례작위대조조。응용전화학발광법진행혈청NSE함량측정。대수족구병조화대조조、EV-71양성조화음성조혈청NSE치진행대비분석。결과수족구병조화대조조비교，혈청NSE수평편고，차이유현저통계학의의(P<0.01)；EV-71양성조화음성조환인비교，혈청NSE수평명현고우음성조，차이유현저통계학의의(P<0.01)。결론수족구병환인혈청NSE수평교정상인동유명현편고， EV-71양성환인최위명현，제시수족구병환인교정상인동역병발신경계통손상，EV-71감염적수족구병환인신경계통손상상대경위엄중。
Objective To explore the effect of EV-71 infection on level of serum neuron-specific enolase (NSE) in children with hand-foot-mouth disease (HFMD). Methods A total of 100 children with HFMD in our hos-pital were randomly collected from April 2011 to November 2012 and enrolled as the HFMD group. The patients were divided into two subgroups according to the results of virus EV-71 antibody detection: EV-71 positive sub-group (n=43) and EV-71 negative subgroup (n=57). Eighty healthy children were selected as the control group. Che-miluminescent methods were performed to detect serum NSE in different groups, which was then compared between the groups. Results Serum NSE level was higher in HFMD group than that in control group (P<0.01), and higher in EV-71 positive subgroup than that in EV-71 negative subgroup (P<0.01). Conclusion The level of serum NSE is higher in children with HFMD than that in healthy children, and it is also significantly higher in EV-71 positive pa-tients, which indicates that children with HFMD predispose to nervous system damage, especially those with virus EV-71 infection.