海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2014年
8期
1130-1132
,共3页
重症肌无力%糖皮质激素%胎盘多肽注射液%临床疗效
重癥肌無力%糖皮質激素%胎盤多肽註射液%臨床療效
중증기무력%당피질격소%태반다태주사액%림상료효
Myasthenia gravis%Glucocorticoid%Placenta polypeptide injection%Curative effect
目的：探讨糖皮质激素(GC)联合胎盘多肽注射液治疗重症肌无力(MG)患者的疗效及安全性。方法124例MG患者被随机分为对照组和观察组，每组均为62例。对照组静脉滴注GC+甲泼尼龙+醋酸泼尼松，观察组在对照组基础上静脉注射胎盘多肽注射液。观察和比较两组临床疗效、治疗前后患者受累肌群肌无力严重程度绝对评分和相对评分、T淋巴细胞转化率、外周血免疫球蛋白和补体水平的变化以及不良反应情况。结果治疗后观察组患者受累肌群肌无力严重程度绝对评分为(10.18±4.11)分，显著低于对照组绝对评分(P<0.05)；相对积分为(60.39±14.05)%，显著低于对照组(P<0.05)；观察组治愈率、显效率和总有效率分别达到11.29%、46.77%和88.52%，显著高于对照组(P<0.05)；治疗后T淋巴细胞转化率达到(65.07±14.16)%，显著高于治疗前和对照组水平(P<0.05)；总不良反应率为14.52%，显著低于对照组(P<0.05)。结论胎盘多肽注射液可提高糖皮质激素治疗重症肌无力患者T淋巴细胞转化率，增强MG患者免疫力和抵抗力，综合疗效优于单用糖皮质激素。
目的：探討糖皮質激素(GC)聯閤胎盤多肽註射液治療重癥肌無力(MG)患者的療效及安全性。方法124例MG患者被隨機分為對照組和觀察組，每組均為62例。對照組靜脈滴註GC+甲潑尼龍+醋痠潑尼鬆，觀察組在對照組基礎上靜脈註射胎盤多肽註射液。觀察和比較兩組臨床療效、治療前後患者受纍肌群肌無力嚴重程度絕對評分和相對評分、T淋巴細胞轉化率、外週血免疫毬蛋白和補體水平的變化以及不良反應情況。結果治療後觀察組患者受纍肌群肌無力嚴重程度絕對評分為(10.18±4.11)分，顯著低于對照組絕對評分(P<0.05)；相對積分為(60.39±14.05)%，顯著低于對照組(P<0.05)；觀察組治愈率、顯效率和總有效率分彆達到11.29%、46.77%和88.52%，顯著高于對照組(P<0.05)；治療後T淋巴細胞轉化率達到(65.07±14.16)%，顯著高于治療前和對照組水平(P<0.05)；總不良反應率為14.52%，顯著低于對照組(P<0.05)。結論胎盤多肽註射液可提高糖皮質激素治療重癥肌無力患者T淋巴細胞轉化率，增彊MG患者免疫力和牴抗力，綜閤療效優于單用糖皮質激素。
목적：탐토당피질격소(GC)연합태반다태주사액치료중증기무력(MG)환자적료효급안전성。방법124례MG환자피수궤분위대조조화관찰조，매조균위62례。대조조정맥적주GC+갑발니룡+작산발니송，관찰조재대조조기출상정맥주사태반다태주사액。관찰화비교량조림상료효、치료전후환자수루기군기무력엄중정도절대평분화상대평분、T림파세포전화솔、외주혈면역구단백화보체수평적변화이급불량반응정황。결과치료후관찰조환자수루기군기무력엄중정도절대평분위(10.18±4.11)분，현저저우대조조절대평분(P<0.05)；상대적분위(60.39±14.05)%，현저저우대조조(P<0.05)；관찰조치유솔、현효솔화총유효솔분별체도11.29%、46.77%화88.52%，현저고우대조조(P<0.05)；치료후T림파세포전화솔체도(65.07±14.16)%，현저고우치료전화대조조수평(P<0.05)；총불량반응솔위14.52%，현저저우대조조(P<0.05)。결론태반다태주사액가제고당피질격소치료중증기무력환자T림파세포전화솔，증강MG환자면역력화저항력，종합료효우우단용당피질격소。
Objective To investigate the curative effect and safety of glucocorticoid (GC) combined with placenta polypeptide injection in the treatment of patients with myasthenia gravis (MG). Methods One hundred and twenty-four patients with MG were randomly divided into the control group and the observation group, with 62 cases in each group. The control group received intravenous injection of GC, methylprednisolone and prednisone acetate, while the observation group received intravenous injection of placenta polypeptide based on the control group. The clinical curative effect, the absolute score and relative score of gravis severity of patients' tired muscles, transforma-tion rate of T lymphocyte, changes of peripheral blood immunoglobulin and complement levels, as well as adverse re-actions of two groups before and after treatment were observed and compared. Results The absolute scores of the ob-servation group after treatment was (10.18±4.11), significantly lower than that of the control group (P<0.05). The rela-tive score of the observation group after treatment was (60.39 ± 14.05), significantly lower than that of the control group (P<0.05). The cure rate, markedly effective rate and total effective rate of the observation group reached 11.29%, 46.77%and 88.52%respectively, significantly higher than those of the control group (P<0.05). The transfor-mation rate of T lymphocyte reached (65.07 ± 14.16)%, significantly higher than that of the control group (P<0.05). The rate of adverse reactions was 14.52%, significantly lower than the control group (P<0.05). Conclusion The pla-centa polypeptide injection could improve the transformation rate of T lymphocyte, enhance immunity and resistance of glucocorticoid in the treatment of patients with myasthenia gravis, and the comprehensive curative effect is better than single glucocorticoid.
