CAJ | 학술논문

目的：探讨促性腺激素释放激素激动剂（GnRHa）在子宫内膜异位症患者保守性手术后应用的临床效果及安全性。方法将本院收治的60例子宫内膜异位症患者随机分为实验组和对照组，两组患者均给予保守性手术治疗，实验组患者在术后给予曲普瑞林治疗。比较两组患者临床治疗的有效率并观察用药期间不良反应的发生情况，随访3年后观察两组患者1年、2年、3年的累计妊娠率及复发率。结果实验组治疗的有效率及1年、2年、3年的累计妊娠率均显著高于对照组(P<0.05)；而实验组累积1年、2年、3年累积复发率显著低于对照组(P<0.05)。实验组治疗期间可见潮热、阴道干、性欲减退等轻微不良反应，所有患者均可耐受。结论 GnRHa应用于子宫内膜异位症患者保守性手术后，可以显著提高临床疗效，促进妊娠，降低复发率，且安全性较高，值得临床推广应用。
목적：탐토촉성선격소석방격소격동제（GnRHa）재자궁내막이위증환자보수성수술후응용적림상효과급안전성。방법장본원수치적60례자궁내막이위증환자수궤분위실험조화대조조，량조환자균급여보수성수술치료，실험조환자재술후급여곡보서림치료。비교량조환자림상치료적유효솔병관찰용약기간불량반응적발생정황，수방3년후관찰량조환자1년、2년、3년적루계임신솔급복발솔。결과실험조치료적유효솔급1년、2년、3년적루계임신솔균현저고우대조조(P<0.05)；이실험조루적1년、2년、3년루적복발솔현저저우대조조(P<0.05)。실험조치료기간가견조열、음도간、성욕감퇴등경미불량반응，소유환자균가내수。결론 GnRHa응용우자궁내막이위증환자보수성수술후，가이현저제고림상료효，촉진임신，강저복발솔，차안전성교고，치득림상추엄응용。
Objective To investigate the clinical effect and security of gonadotropin-releasing hormone ago-nist (GnRHa) for patients with endometriosis after conservative surgery. Methods Sixty patients of uterine endome-triosis in our hospital were randomly divided into the experimental group and the control group. The two groups of pa-tients were treated with conservative surgery, while patients of the experimental group were given triptorelin treat-ment. The clinical efficacy of the two groups was compared and the occurrence of side reactions was observed during the treatment. The 1-year, 2-year, 3-year cumulative pregnancy rate and recurrence rate were observed in the 3-year follow-up. Results The clinical efficacy, the 1-year, 2-year, 3-year cumulative pregnancy rate of the experimental group were significantly higher than those of the control group (P<0.05); 1-year, 2-year, 3-year cumulative recur-rence rate of the experimental group were significantly lower than those of the control group (P<0.05). There were mild adverse reactions such as hot flashes, vaginal dryness, and loss of libido during treatment in the experimental group, which were tolerated by all patients. Conclusion GnRHa applied to patients with endometriosis after conser-vative surgery can significantly improve the clinical efficacy, promote pregnancy, reduce the relapse rate, and is of high security, which is worthy of clinical application.