CAJ | 학술논문

目的：探讨S100B蛋白水平与帕金森病临床分期的关系。方法对符合入选标准的帕金森病患者作为帕金森病组(35例)，登记病史及进行详细查体，进行Hoehn-Yahr分期，并用日常生活活动能力量表(Activity of Daily life，ADL)评定PD患者日常生活能力；同时收集与帕金森病组年龄、性别、教育程度等相匹配的同期健康体检者作为对照组(35名)。两组均测定空腹血S100B蛋白水平，对结果进行相应的统计学分析。结果帕金森病组血S100B水平明显高于对照组[(0.0998±0.0491)μg/L vs (0.0503±0.0395)μg/L](t=4.653，P=0.000)；帕金森病患者Hoehn-Yahr分期各期之间的血S100B水平相比较呈正相关(r=0.812，P=0.000)。结论血清S100B蛋白与帕金森病人Hoehn-Yahr分期及日常生活活动能力具有相关性，可以作为反映病情严重程度的一个指标。
목적：탐토S100B단백수평여파금삼병림상분기적관계。방법대부합입선표준적파금삼병환자작위파금삼병조(35례)，등기병사급진행상세사체，진행Hoehn-Yahr분기，병용일상생활활동능역량표(Activity of Daily life，ADL)평정PD환자일상생활능력；동시수집여파금삼병조년령、성별、교육정도등상필배적동기건강체검자작위대조조(35명)。량조균측정공복혈S100B단백수평，대결과진행상응적통계학분석。결과파금삼병조혈S100B수평명현고우대조조[(0.0998±0.0491)μg/L vs (0.0503±0.0395)μg/L](t=4.653，P=0.000)；파금삼병환자Hoehn-Yahr분기각기지간적혈S100B수평상비교정정상관(r=0.812，P=0.000)。결론혈청S100B단백여파금삼병인Hoehn-Yahr분기급일상생활활동능력구유상관성，가이작위반영병정엄중정도적일개지표。
Objective To study the correlation between serum S100B protein level and the clinical stages of Parkinson's disease (PD). Methods 35 patients with PD were enrolled as PD group, whose detailed physical exami-nation and medical history were recorded and the Hoehn-Yahr stage of these patients were determined. Activity of dai-ly life scale was performed to evaluate the activity of daily living of these patients. At the same period, 35 healthy peo-ple with matching age, gender and educational status of PD group were enrolled as control group. The limosis serum levels of S100B in both groups were detected and the results were statistically analysed. Results The levels of S100B protein in PD group (0.099 8 ± 0.049 1) μg/L were significantly higher than that in control group (0.050 3 ± 0.039 5) μg/L. The S100B protein levels from different Hoehn-Yahr stage had a positive correlation with the corresponding Hoehn-Yahr stage (r=0.812,P=0.000). Conclusion The level of serum S100B protein is related to the Hoehn-Yahr stage of PD and the activity of daily living of patients. S100B can be used to determine the severity of PD.