CAJ | 학술논문

目的：研究胱抑素C（Cys C）的表达与乙型病毒性肝炎后肝硬化患者肾功能损害程度的相关性。方法选择160例乙型病毒性肝炎肝硬化合并肾功能损害患者作为观察组，45例乙型病毒性肝炎肝硬化且未出现肾功能损害的患者作为对照组，检测肾功能指标和Cys C水平。结果与对照组相比，观察组中肾功能Ⅰ、Ⅱ级亚组患者的 Scr[（62.31±8.85）μmol/L、（63．58±8．01）μmol/L]、Urea 水平[（4．66±0．77）μmol/L、（4．71±0.82）mmol/L]差异无统计学意义，Cys C水平明显升高且表现肾功能Ⅰ级亚组[（1．03±0.21）mg/L]＜Ⅱ级亚组[（1．38±0．28）mg/L]＜Ⅲ级亚组[（1．71±0．35）mg/L]＜Ⅳ级亚组[（1．97±0．41） mg/L]；胱抑素C水平与内生肌酐清除率、Ccr呈负相关，与血肌酐、血尿素氮水平呈正相关。结论 Cys C水平与肾功能密切相关并且能够早期反映肾功能损害，其含量越高、肾功能越差。
목적：연구광억소C（Cys C）적표체여을형병독성간염후간경화환자신공능손해정도적상관성。방법선택160례을형병독성간염간경화합병신공능손해환자작위관찰조，45례을형병독성간염간경화차미출현신공능손해적환자작위대조조，검측신공능지표화Cys C수평。결과여대조조상비，관찰조중신공능Ⅰ、Ⅱ급아조환자적 Scr[（62.31±8.85）μmol/L、（63．58±8．01）μmol/L]、Urea 수평[（4．66±0．77）μmol/L、（4．71±0.82）mmol/L]차이무통계학의의，Cys C수평명현승고차표현신공능Ⅰ급아조[（1．03±0.21）mg/L]＜Ⅱ급아조[（1．38±0．28）mg/L]＜Ⅲ급아조[（1．71±0．35）mg/L]＜Ⅳ급아조[（1．97±0．41） mg/L]；광억소C수평여내생기항청제솔、Ccr정부상관，여혈기항、혈뇨소담수평정정상관。결론 Cys C수평여신공능밀절상관병차능구조기반영신공능손해，기함량월고、신공능월차。
Objective To study the correlation between cystatin C and degree of renal function damage in patients with liver cirrhosis .Methods 160 cases patients of liver cirrhosis combined with renal damage were selected as the observation group and 45 cases patients of normal renal function as the control group .Then renal function inde-xes and cystatin C levels were observed.Results Compared with control group,Scr[(62.31 ±8.85)μmol/L, (63.58 ±8.01)μmol/L],Urea[(4.66 ±0.77)μmol/L,(4.71 ±0.82)μmol/L] level of renal functionⅠ,Ⅱsub-groups in the observation group had no significant differences .Cys C level was significantly lower than that of the con-trol group and showed renal function Ⅰsubgroup[(1.03 ±0.21)mg/L] <II subgroup[(1.38 ±0.28)mg/L] <III subgroup[(1.71 ±0.35)mg/L] <IV subgroup[(1.97 ±0.41)mg/L];Cys C level negatively correlated with Ccr and positively correlated with Scr and Urea .Conclusion Cys C level is closely related to renal function and can re-flect early renal function damage ,as the level of Cys C gets higher ,the renal function becomes worse .