CAJ | 학술논문

目的：观察三七总皂苷（ PNS）治疗慢性阻塞性肺疾病急性加重（ AECOPD）合并呼吸衰竭患者血清环氧化酶-2（COX-2）、前列腺素E2（PGE-2）和磷脂酶A-2（PLA-2）水平的变化。方法对100例COPD合并呼吸衰竭患者随机分为常规药物组和三七皂苷组，观察两组治疗前后血清COX-2、PGE-2和PLA-2的变化。结果治疗后血清COX-2、PGE-2和PLA-2水平均明显下降，而三七皂苷组下降显著，差异有统计学意义（ P＜0．05）。结论三七总皂苷可降低COPD合并呼吸衰竭患者的血清COX-2、PGE-2和PLA-2的浓度，抑制炎性介质的生成和释放，减少气道阻塞，改善呼吸衰竭。
목적：관찰삼칠총조감（ PNS）치료만성조새성폐질병급성가중（ AECOPD）합병호흡쇠갈환자혈청배양화매-2（COX-2）、전렬선소E2（PGE-2）화린지매A-2（PLA-2）수평적변화。방법대100례COPD합병호흡쇠갈환자수궤분위상규약물조화삼칠조감조，관찰량조치료전후혈청COX-2、PGE-2화PLA-2적변화。결과치료후혈청COX-2、PGE-2화PLA-2수평균명현하강，이삼칠조감조하강현저，차이유통계학의의（ P＜0．05）。결론삼칠총조감가강저COPD합병호흡쇠갈환자적혈청COX-2、PGE-2화PLA-2적농도，억제염성개질적생성화석방，감소기도조새，개선호흡쇠갈。
Objective To investigate influence of Panax notoginseng saponins ( PNS) on Cyclooxygenase-2 (COX-2),Prostaglandin E2(PGE-2)and Phospholipases A2(PLA-2)in patients of acute exacerbation of chronic ob-structive pulmonary disease ( AECOPD) with respiratory failure .Methods One hundred AECOPD patients with re-spiratory failure were divided into the control group (n=50)and PNS group(n=50).The levels of blood serum COX-2,PGE-2 and PLA-2 of patients in the two groups were detected .Results The levels of blood serum COX-2,PGE-2 and PLA-2 of patients in PNS group were lower than those in control group ,the two groups after treatment significantly lower than those before treatment(P<0.05).Conclusion The levels of COX-2,PGE-2 and PLA-2 have influence on respiratory failure.PNS can reduce the COX-2,PGE-2 and PLA-2 concentrations in blood serum of patients ,mean-while it play a prominent role in inhibiting airway inflammatory and obstruction process .