CAJ | 학술논문

目的：应用关联规则的方法探讨中药治疗手足口病用药规律。方法在中国知网、万方、维普资源系统搜索2000年1月至2012年12月有关中药治疗手足口病的中文文献，选取临床报道治疗无不良反应，治疗例数在20例以上，有关治疗手足口病内服汤剂154副，用关联规则方法中的Aprion算法分析方剂中药对的应用规律。结果在154副中药复方中共使用158种药物2011频次。其中，使用频次在40次以上的依次为金银花、连翘、生石膏等13味中药，使用总频次为978次，关联规则方法分析得出高频使用支持度和置信度排序在前15位的药组有18组，其中高频复合药对有12组。结论运用关联规则等数据挖掘方法，可较好地发现中医治疗手足口病复方中药对用药的规律，为临床规范遣方用药提供理论指导。
목적：응용관련규칙적방법탐토중약치료수족구병용약규률。방법재중국지망、만방、유보자원계통수색2000년1월지2012년12월유관중약치료수족구병적중문문헌，선취림상보도치료무불량반응，치료례수재20례이상，유관치료수족구병내복탕제154부，용관련규칙방법중적Aprion산법분석방제중약대적응용규률。결과재154부중약복방중공사용158충약물2011빈차。기중，사용빈차재40차이상적의차위금은화、련교、생석고등13미중약，사용총빈차위978차，관련규칙방법분석득출고빈사용지지도화치신도배서재전15위적약조유18조，기중고빈복합약대유12조。결론운용관련규칙등수거알굴방법，가교호지발현중의치료수족구병복방중약대용약적규률，위림상규범견방용약제공이론지도。
Objective To discuss the rule of medication of traditional Chinese medicine in treating Hand-foot-mouth disease by using association rules. Methods Articles about traditional Chinese medicine treating Hand-foot-mouth disease were collected from CNKI, Weipu, WANFANG DATA from January 2000 to December 2012. From those articles, 154 traditional Chinese oral decoctions with no adverse reaction were selected. Meanwhile, in those selections, the case number was above 20. Aprion algorithm was employed to analyze the application law of medicine pair in prescription. Results In the 154 Chinese herbal compounds, 158 drugs were used for 2011 times. Among them, honeysuckle flower, forsythia, gypsum and other 13 kinds were used more than 40 times, and the total frequency of utilization was 978. There were 18 high frequently used medicine pairs ranking in the top 15 of the as-sociation rule analysis. Among those pairs, medicine pair from heat clearing drugs occupied 15 groups, medicine pair from heat-clearing drugs and antipyretics occupied 2 groups, and medicine pair from diaphoretic occupied 1 group. Conclusion By using association rules, the law of medicine pair in traditional Chinese medicine com-pounds could be better discovered in treating Hand-foot-mouth disease, which will provide theoretical guidance to clinical medication.